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sirt1 sirtuin 1 [ Danio rerio (zebrafish) ]

Gene ID: 797132, updated on 16-Sep-2018

Summary

Official Symbol
sirt1provided by ZNC
Official Full Name
sirtuin 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-070801-2
See related
Ensembl:ENSDARG00000068064
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
Also known as
im:7148963
Orthologs

Genomic context

See sirt1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (50348961..50366862, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (50035732..50053619, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene myopalladin Neighboring gene CDK2 associated cullin domain 1 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 12 Neighboring gene cytochrome c oxidase subunit 5B2

Genomic regions, transcripts, and products

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity (H3-K9 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bHLH transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
p53 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein C-terminus binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein domain specific binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gliogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of gliogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nuclear euchromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rDNA heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1
Names
sirtuin (silent mating type information regulation 2 homolog) 1

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    50348961..50366862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173034.3XP_005173091.1  NAD-dependent protein deacetylase sirtuin-1 isoform X2

    Conserved Domains (1) summary
    cd01408
    Location:190425
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
  2. XM_001334404.6XP_001334440.4  NAD-dependent protein deacetylase sirtuin-1 isoform X1

    UniProtKB/TrEMBL
    E7F8W3
    Related
    ENSDARP00000088981.3, ENSDART00000098209.5
    Conserved Domains (1) summary
    cd01408
    Location:190425
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
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