Format

Send to:

Choose Destination

IPO4 importin 4 [ Homo sapiens (human) ]

Gene ID: 79711, updated on 9-Feb-2020

Summary

Official Symbol
IPO4provided by HGNC
Official Full Name
importin 4provided by HGNC
Primary source
HGNC:HGNC:19426
See related
Ensembl:ENSG00000196497
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Imp4
Expression
Broad expression in testis (RPKM 33.8), thyroid (RPKM 8.4) and 25 other tissues See more
Orthologs

Genomic context

See IPO4 in Genome Data Viewer
Location:
14q12
Exon count:
30
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (24180219..24188918, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24649425..24658124, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ring finger protein 31 Neighboring gene RNA, 5S ribosomal pseudogene 383 Neighboring gene interferon regulatory factor 9 Neighboring gene REC8 meiotic recombination protein Neighboring gene transmembrane 9 superfamily member 1 Neighboring gene testis specific serine kinase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol HIV-1 IN is identified to have a physical interaction with importin 4 (IPO4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TM9SF1

Homology

Clone Names

  • FLJ23338, MGC131665

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ran GTPase binding IEA
Inferred from Electronic Annotation
more info
 
nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication-dependent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication-independent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
importin-4
Names
imp4b
importin-4b
ran-binding protein 4
ranBP4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024658.4NP_078934.3  importin-4

    See identical proteins and their annotated locations for NP_078934.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript.
    Source sequence(s)
    AK056527, AK094897, BC003690
    Consensus CDS
    CCDS9616.1
    UniProtKB/Swiss-Prot
    Q8TEX9
    UniProtKB/TrEMBL
    B3KT38
    Related
    ENSP00000346453.6, ENST00000354464.11
    Conserved Domains (4) summary
    smart00913
    Location:2490
    IBN_N; Importin-beta N-terminal domain
    cd00020
    Location:355467
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam13646
    Location:392505
    HEAT_2; HEAT repeats
    sd00044
    Location:353381
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_051979.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate segment in the coding region, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK094897, BC144399, BG333193
    Related
    ENST00000560155.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    24180219..24188918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p13 PATCHES

    Range
    481197..489896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center