Format

Send to:

Choose Destination

MANEA mannosidase endo-alpha [ Homo sapiens (human) ]

Gene ID: 79694, updated on 5-Sep-2021

Summary

Official Symbol
MANEAprovided by HGNC
Official Full Name
mannosidase endo-alphaprovided by HGNC
Primary source
HGNC:HGNC:21072
See related
Ensembl:ENSG00000172469 MIM:612327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ENDO; hEndo
Summary
N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]).[supplied by OMIM, Sep 2008]
Expression
Ubiquitous expression in urinary bladder (RPKM 7.3), thyroid (RPKM 6.8) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MANEA in Genome Data Viewer
Location:
6q16.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (95577535..95609452)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (96025411..96057328)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CYCS pseudogene 17 Neighboring gene MANEA divergent transcript Neighboring gene uncharacterized LOC107986543 Neighboring gene uncharacterized LOC107986626 Neighboring gene keratin 18 pseudogene 50

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed
Envelope transmembrane glycoprotein gp41 env Specific alterations of the N-linked carbohydrates on HIV-1 gp120 and gp41 by glucosidases and mannosidase inhibitors can enhance mannose-binding lectin (MBL)-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL PubMed
env Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ12838, DKFZp686D20120

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glycoprotein endo-alpha-1,2-mannosidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycoprotein endo-alpha-1,2-mannosidase activity TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glycoprotein endo-alpha-1,2-mannosidase
Names
alpha 1,2-endomannosidase
endo-alpha mannosidase
endomannosidase
mandaselin
NP_078917.2
XP_005267204.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024641.4NP_078917.2  glycoprotein endo-alpha-1,2-mannosidase

    See identical proteins and their annotated locations for NP_078917.2

    Status: VALIDATED

    Source sequence(s)
    BC137014, BQ018032, BX481372, BX537398
    Consensus CDS
    CCDS5032.1
    UniProtKB/Swiss-Prot
    Q5SRI9
    Related
    ENSP00000351669.4, ENST00000358812.9
    Conserved Domains (1) summary
    pfam16317
    Location:98448
    Glyco_hydro_99; Glycosyl hydrolase family 99

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    95577535..95609452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267147.3XP_005267204.1  glycoprotein endo-alpha-1,2-mannosidase isoform X1

    See identical proteins and their annotated locations for XP_005267204.1

    UniProtKB/Swiss-Prot
    Q5SRI9
    Related
    ENSP00000507267.1, ENST00000682663.1
    Conserved Domains (1) summary
    pfam16317
    Location:98448
    Glyco_hydro_99; Glycosyl hydrolase family 99
Support Center