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QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 [ Homo sapiens (human) ]

Gene ID: 79691, updated on 18-Aug-2020

Summary

Official Symbol
QTRT2provided by HGNC
Official Full Name
queuine tRNA-ribosyltransferase accessory subunit 2provided by HGNC
Primary source
HGNC:HGNC:25771
See related
Ensembl:ENSG00000151576
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QTRTD1
Summary
This gene encodes a subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine, and tyrosine. The encoded protein may play a role in the queuosine 5'-monophosphate salvage pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in lymph node (RPKM 5.0), spleen (RPKM 4.9) and 25 other tissues See more
Orthologs

Genomic context

See QTRT2 in Genome Data Viewer
Location:
3q13.31
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (114056737..114088422)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (113775582..113807269)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type palmitoyltransferase 23 Neighboring gene coiled-coil domain containing 191 Neighboring gene ATP synthase peripheral stalk-membrane subunit b pseudogene Neighboring gene uncharacterized LOC105374048 Neighboring gene H2B histone pseudogene 3 Neighboring gene dopamine receptor D3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12960

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to queuine tRNA-ribosyltransferase activity IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
tRNA modification TAS
Traceable Author Statement
more info
 
tRNA-guanine transglycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA-guanine transglycosylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
queuine tRNA-ribosyltransferase accessory subunit 2
Names
queuine tRNA-ribosyltransferase domain containing 1
NP_001243764.1
NP_001243765.1
NP_001243766.1
NP_078914.1
XP_005247826.1
XP_005247827.1
XP_006713807.1
XP_011511439.1
XP_016862671.1
XP_016862672.1
XP_016862673.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256835.2NP_001243764.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' region and initiates translation at an upstream start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    BC034559, BC039265, DC400836
    Consensus CDS
    CCDS58844.1
    UniProtKB/Swiss-Prot
    Q9H974
    Related
    ENSP00000420682.1, ENST00000485050.5
    Conserved Domains (1) summary
    pfam01702
    Location:146420
    TGT; Queuine tRNA-ribosyltransferase
  2. NM_001256836.2NP_001243765.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 3

    See identical proteins and their annotated locations for NP_001243765.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks four consecutive internal exons and initiates translation at an upstream start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK296938, BC034559, BC039265, DC400836
    Consensus CDS
    CCDS58845.1
    UniProtKB/Swiss-Prot
    Q9H974
    Related
    ENSP00000419169.1, ENST00000493014.1
    Conserved Domains (1) summary
    pfam01702
    Location:28302
    TGT; Queuine tRNA-ribosyltransferase
  3. NM_001256837.2NP_001243766.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 4

    See identical proteins and their annotated locations for NP_001243766.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two internal exons, uses an alternate splice site and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK299313, BC034559, BC039265, DC400836
    Consensus CDS
    CCDS58846.1
    UniProtKB/Swiss-Prot
    Q9H974
    Related
    ENSP00000418056.1, ENST00000479882.5
    Conserved Domains (1) summary
    pfam01702
    Location:11285
    TGT; Queuine tRNA-ribosyltransferase
  4. NM_024638.4NP_078914.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_078914.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    BC034559, BC039265, DC400836
    Consensus CDS
    CCDS33828.1
    UniProtKB/Swiss-Prot
    Q9H974
    Related
    ENSP00000281273.4, ENST00000281273.8
    Conserved Domains (1) summary
    pfam01702
    Location:134408
    TGT; Queuine tRNA-ribosyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    114056737..114088422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713744.4XP_006713807.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_006713807.1

    Conserved Domains (1) summary
    pfam01702
    Location:48322
    TGT; Queuine tRNA-ribosyltransferase
  2. XM_017007183.2XP_016862672.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X3

    UniProtKB/Swiss-Prot
    Q9H974
    Conserved Domains (1) summary
    pfam01702
    Location:11285
    TGT; Queuine tRNA-ribosyltransferase
  3. XM_017007184.2XP_016862673.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X4

  4. XM_011513137.3XP_011511439.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X1

    Conserved Domains (1) summary
    pfam01702
    Location:146301
    TGT; Queuine tRNA-ribosyltransferase
  5. XM_005247769.4XP_005247826.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_005247826.1

    Conserved Domains (1) summary
    pfam01702
    Location:48322
    TGT; Queuine tRNA-ribosyltransferase
  6. XM_005247770.3XP_005247827.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X3

    See identical proteins and their annotated locations for XP_005247827.1

    UniProtKB/Swiss-Prot
    Q9H974
    Conserved Domains (1) summary
    pfam01702
    Location:11285
    TGT; Queuine tRNA-ribosyltransferase
  7. XM_017007182.1XP_016862671.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X3

    UniProtKB/Swiss-Prot
    Q9H974
    Conserved Domains (1) summary
    pfam01702
    Location:11285
    TGT; Queuine tRNA-ribosyltransferase

RNA

  1. XR_002959585.1 RNA Sequence

  2. XR_001740268.2 RNA Sequence

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