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GAL3ST4 galactose-3-O-sulfotransferase 4 [ Homo sapiens (human) ]

Gene ID: 79690, updated on 18-Aug-2020

Summary

Official Symbol
GAL3ST4provided by HGNC
Official Full Name
galactose-3-O-sulfotransferase 4provided by HGNC
Primary source
HGNC:HGNC:24145
See related
Ensembl:ENSG00000197093 MIM:608235
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAL3ST-4
Summary
This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate to the C-3' position of galactose residues in O-linked glycoproteins. This enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 11.3), salivary gland (RPKM 5.3) and 21 other tissues See more
Orthologs

Genomic context

See GAL3ST4 in Genome Data Viewer
Location:
7q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100159244..100168617, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99756865..99766373, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene 60 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Neighboring gene trafficking protein particle complex 14 Neighboring gene microRNA 4658 Neighboring gene glypican 2 Neighboring gene stromal antigen 3 Neighboring gene 60S ribosomal protein L29-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: GPC2

Homology

Clone Names

  • FLJ12116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate binding NAS
Non-traceable Author Statement
more info
PubMed 
galactose 3-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
galactose 3-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
galactosylceramide sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
proteoglycan sulfotransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell-cell signaling NAS
Non-traceable Author Statement
more info
PubMed 
glycolipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
glycoprotein biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
glycoprotein metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
oligosaccharide metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
proteoglycan biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
sulfur compound metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
galactose-3-O-sulfotransferase 4
Names
beta-galactose-3-O-sulfotransferase 4
gal-beta-1,3-GalNAc 3'-sulfotransferase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024637.5NP_078913.3  galactose-3-O-sulfotransferase 4

    See identical proteins and their annotated locations for NP_078913.3

    Status: REVIEWED

    Source sequence(s)
    AC073842, AF316113
    Consensus CDS
    CCDS5688.1
    UniProtKB/Swiss-Prot
    Q96RP7
    Related
    ENSP00000353142.4, ENST00000360039.9
    Conserved Domains (1) summary
    cl22970
    Location:18469
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100159244..100168617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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