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ZDHHC14 zinc finger DHHC-type palmitoyltransferase 14 [ Homo sapiens (human) ]

Gene ID: 79683, updated on 5-Aug-2022

Summary

Official Symbol
ZDHHC14provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 14provided by HGNC
Primary source
HGNC:HGNC:20341
See related
Ensembl:ENSG00000175048 MIM:619295; AllianceGenome:HGNC:20341
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEW1CP
Summary
Enables palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 2.5), endometrium (RPKM 2.3) and 24 other tissues See more
Orthologs
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Genomic context

See ZDHHC14 in Genome Data Viewer
Location:
6q25.3
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (157381190..157678157)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (158623184..158920181)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (157802222..158099189)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene chromosome 18 open reading frame 21 pseudogene Neighboring gene uncharacterized LOC124901446 Neighboring gene Sharpr-MPRA regulatory region 985 Neighboring gene microRNA 3692 Neighboring gene uncharacterized LOC107986663 Neighboring gene U2 spliceosomal RNA Neighboring gene Sharpr-MPRA regulatory region 4686

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20984

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC14
Names
DHHC domain-containing cysteine-rich protein 14
DHHC-14
NEW1 domain-containing protein
probable palmitoyltransferase ZDHHC14
zinc finger DHHC domain-containing protein 14
zinc finger DHHC-type containing 14
zinc finger, DHHC domain containing 14
NP_078906.2
NP_714968.1
XP_016866797.1
XP_016866798.1
XP_016866799.1
XP_047275322.1
XP_047275324.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024630.3NP_078906.2  palmitoyltransferase ZDHHC14 isoform 1

    See identical proteins and their annotated locations for NP_078906.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF542388, AL117344, AL133510
    Consensus CDS
    CCDS5252.1
    UniProtKB/Swiss-Prot
    Q8IZN3, Q9H7F1
    Related
    ENSP00000352821.5, ENST00000359775.10
    Conserved Domains (2) summary
    PHA03247
    Location:314485
    PHA03247; large tegument protein UL36; Provisional
    pfam01529
    Location:164287
    DHHC; DHHC palmitoyltransferase
  2. NM_153746.2NP_714968.1  palmitoyltransferase ZDHHC14 isoform 2

    See identical proteins and their annotated locations for NP_714968.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AF542389, AL117344
    Consensus CDS
    CCDS47510.1
    UniProtKB/Swiss-Prot
    Q8IZN3
    Related
    ENSP00000410713.2, ENST00000414563.6
    Conserved Domains (2) summary
    PHA03247
    Location:314470
    PHA03247; large tegument protein UL36; Provisional
    pfam01529
    Location:164287
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    157381190..157678157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419366.1XP_047275322.1  palmitoyltransferase ZDHHC14 isoform X3

  2. XM_017011308.2XP_016866797.1  palmitoyltransferase ZDHHC14 isoform X1

  3. XM_017011309.2XP_016866798.1  palmitoyltransferase ZDHHC14 isoform X2

  4. XM_017011310.2XP_016866799.1  palmitoyltransferase ZDHHC14 isoform X4

  5. XM_047419368.1XP_047275324.1  palmitoyltransferase ZDHHC14 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    158623184..158920181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)