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FASTKD1 FAST kinase domains 1 [ Homo sapiens (human) ]

Gene ID: 79675, updated on 21-Dec-2019

Summary

Official Symbol
FASTKD1provided by HGNC
Official Full Name
FAST kinase domains 1provided by HGNC
Primary source
HGNC:HGNC:26150
See related
Ensembl:ENSG00000138399 MIM:617529
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in heart (RPKM 4.3), duodenum (RPKM 3.9) and 25 other tissues See more
Orthologs

Genomic context

See FASTKD1 in Genome Data Viewer
Location:
2q31.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (169527880..169573921, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170386259..170430431, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Bardet-Biedl syndrome 5 Neighboring gene kelch like family member 41 Neighboring gene peptidylprolyl isomerase G Neighboring gene CYFIP related Rac1 interactor B pseudogene Neighboring gene coiled-coil domain containing 173

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21901, KIAA1800

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
mitochondrial RNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of mitochondrial mRNA stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
FAST kinase domain-containing protein 1, mitochondrial

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281476.2NP_001268405.1  FAST kinase domain-containing protein 1, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB058703, AK055892, AL832058, CA449468, DA650481
    Consensus CDS
    CCDS63051.1
    UniProtKB/Swiss-Prot
    Q53R41
    Related
    ENSP00000403229.2, ENST00000453929.6
    Conserved Domains (3) summary
    smart00952
    Location:736795
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:575642
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:657699
    FAST_2; FAST kinase-like protein, subdomain 2
  2. NM_001322046.1NP_001308975.1  FAST kinase domain-containing protein 1, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    AB058703, AC093899, AK055892, AL832058, CA449468, DA650481
    Consensus CDS
    CCDS33318.1
    UniProtKB/Swiss-Prot
    Q53R41
    Conserved Domains (3) summary
    smart00952
    Location:779838
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:575642
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:662742
    FAST_2; FAST kinase-like protein, subdomain 2
  3. NM_001322048.1NP_001308977.1  FAST kinase domain-containing protein 1, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AB058703, AK055892, AL832058, CA449468, DA650481
    UniProtKB/Swiss-Prot
    Q53R41
    UniProtKB/TrEMBL
    D3DPC4
    Conserved Domains (3) summary
    smart00952
    Location:756815
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:552619
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:639719
    FAST_2; FAST kinase-like protein, subdomain 2
  4. NM_001322049.1NP_001308978.1  FAST kinase domain-containing protein 1, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AB058703, AK055892, AL832058, BC017950, BC032687, CA449468, DA650481
    UniProtKB/Swiss-Prot
    Q53R41
    UniProtKB/TrEMBL
    Q05D57
    Conserved Domains (3) summary
    smart00952
    Location:713772
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:552619
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:634676
    FAST_2; FAST kinase-like protein, subdomain 2
  5. NM_024622.6NP_078898.3  FAST kinase domain-containing protein 1, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_078898.3

    Status: VALIDATED

    Source sequence(s)
    AB058703, AK055892, AL832058, CA449468, DA650481
    Consensus CDS
    CCDS33318.1
    UniProtKB/Swiss-Prot
    Q53R41
    Related
    ENSP00000400513.2, ENST00000453153.7
    Conserved Domains (3) summary
    smart00952
    Location:779838
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:575642
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:662742
    FAST_2; FAST kinase-like protein, subdomain 2

RNA

  1. NR_104020.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AB058703, AK055892, AK130797, AL832058, CA449468, DA650481

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    169527880..169573921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004912.2XP_016860401.1  FAST kinase domain-containing protein 1, mitochondrial isoform X4

  2. XM_006712750.4XP_006712813.1  FAST kinase domain-containing protein 1, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006712813.1

    UniProtKB/TrEMBL
    D3DPC4
    Conserved Domains (3) summary
    smart00952
    Location:756815
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:552619
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:639719
    FAST_2; FAST kinase-like protein, subdomain 2
  3. XM_017004911.2XP_016860400.1  FAST kinase domain-containing protein 1, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q53R41
    Conserved Domains (3) summary
    smart00952
    Location:607666
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:403470
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:490570
    FAST_2; FAST kinase-like protein, subdomain 2
  4. XM_006712751.4XP_006712814.1  FAST kinase domain-containing protein 1, mitochondrial isoform X3

    Conserved Domains (3) summary
    smart00952
    Location:459518
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:255322
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:342422
    FAST_2; FAST kinase-like protein, subdomain 2
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