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FN3KRP fructosamine 3 kinase related protein [ Homo sapiens (human) ]

Gene ID: 79672, updated on 5-Aug-2018

Summary

Official Symbol
FN3KRPprovided by HGNC
Official Full Name
fructosamine 3 kinase related proteinprovided by HGNC
Primary source
HGNC:HGNC:25700
See related
Ensembl:ENSG00000141560 MIM:611683; Vega:OTTHUMG00000177846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FN3KL
Summary
A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Expression
Ubiquitous expression in brain (RPKM 19.2), fat (RPKM 14.3) and 25 other tissues See more
Orthologs

Genomic context

See FN3KRP in Genome Data Viewer
Location:
17q25.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (82716706..82728017)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80674582..80685893)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376791 Neighboring gene uncharacterized LOC101929552 Neighboring gene fructosamine 3 kinase Neighboring gene tubulin folding cofactor D Neighboring gene zinc finger protein 750

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry.
NHGRI GWA Catalog
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
NHGRI GWA Catalog
Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12171

Gene Ontology Provided by GOA

Function Evidence Code Pubs
kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ketosamine-3-kinase
Names
FN3K-related protein
testis secretory sperm-binding protein Li 211a

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024619.3NP_078895.2  ketosamine-3-kinase

    See identical proteins and their annotated locations for NP_078895.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC024361, BC001458, BC007611, DA019669
    Consensus CDS
    CCDS11817.1
    UniProtKB/Swiss-Prot
    Q9HA64
    UniProtKB/TrEMBL
    A0A140VK84
    Related
    ENSP00000269373.6, OTTHUMP00000257791, ENST00000269373.10, OTTHUMT00000439219
    Conserved Domains (1) summary
    cl21453
    Location:21309
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_046408.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA766235, AC024361, AK301958

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    82716706..82728017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450948.1XP_024306716.1  ketosamine-3-kinase isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:23188
    PKc_like; Protein Kinases, catalytic domain
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