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TUT7 terminal uridylyl transferase 7 [ Homo sapiens (human) ]

Gene ID: 79670, updated on 13-Mar-2020

Summary

Official Symbol
TUT7provided by HGNC
Official Full Name
terminal uridylyl transferase 7provided by HGNC
Primary source
HGNC:HGNC:25817
See related
Ensembl:ENSG00000083223 MIM:613467
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAPD6; TENT3B; ZCCHC6
Expression
Ubiquitous expression in prostate (RPKM 7.8), skin (RPKM 6.8) and 25 other tissues See more
Orthologs

Genomic context

See TUT7 in Genome Data Viewer
Location:
9q21.33
Exon count:
32
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (86287733..86354497, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (88902648..88969402, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene chromosome 9 open reading frame 153 Neighboring gene RN7SK pseudogene 264 Neighboring gene iron-sulfur cluster assembly 1 Neighboring gene ribosomal protein S6 pseudogene 13 Neighboring gene uncharacterized LOC102724080 Neighboring gene RNA, U2 small nuclear 36, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp666B142, DKFZp686F119, DKFZp686I1269, DKFZp686C11112

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA uridylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
uridylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA 3' uridylation IDA
Inferred from Direct Assay
more info
PubMed 
RNA 3' uridylation ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA 3'-end processing IDA
Inferred from Direct Assay
more info
PubMed 
NOT histone mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
miRNA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transposition, RNA-mediated IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA poly(A) tail shortening TAS
Traceable Author Statement
more info
 
oocyte maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
polyuridylation-dependent mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
pre-miRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
terminal uridylyltransferase 7
Names
PAP associated domain containing 6
TUTase 7
zinc finger CCHC domain-containing protein 6
zinc finger CCHC-type containing 6
zinc finger, CCHC domain containing 6
NP_001171988.1
NP_001172003.1
NP_001317647.1
NP_078893.2
XP_005252264.1
XP_005252265.1
XP_006717346.1
XP_011517313.1
XP_011517314.1
XP_011517315.1
XP_011517316.1
XP_011517317.1
XP_011517318.1
XP_016870619.1
XP_016870620.1
XP_024303439.1
XP_024303440.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185059.2NP_001171988.1  terminal uridylyltransferase 7 isoform 1

    See identical proteins and their annotated locations for NP_001171988.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein isoform.
    Source sequence(s)
    AK055546, AK055948, BC015897, CR933643
    Consensus CDS
    CCDS35057.1
    UniProtKB/Swiss-Prot
    Q5VYS8
    Conserved Domains (4) summary
    cd05402
    Location:10211138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:14521468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:12331286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:13711450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
  2. NM_001185074.2NP_001172003.1  terminal uridylyltransferase 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two different regions of sequence, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK055546, AL832026, BC015897, BU734789, CA773862
    Consensus CDS
    CCDS55323.1
    UniProtKB/Swiss-Prot
    Q5VYS8
    Related
    ENSP00000365127.2, ENST00000375960.6
    Conserved Domains (5) summary
    cd05402
    Location:830902
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:12161232
    ZnF_C2HC; zinc finger
    pfam03828
    Location:9971050
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:11351214
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    cl11966
    Location:315360
    NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
  3. NM_001330718.2NP_001317647.1  terminal uridylyltransferase 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK055948, AL137849, AL353678, CN419677, CR933643, CR933644, DB156789
    Consensus CDS
    CCDS83383.1
    UniProtKB/Swiss-Prot
    Q5VYS8
    UniProtKB/TrEMBL
    X6R3Q3
    Related
    ENSP00000277141.6, ENST00000277141.10
  4. NM_024617.4NP_078893.2  terminal uridylyltransferase 7 isoform 1

    See identical proteins and their annotated locations for NP_078893.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein isoform.
    Source sequence(s)
    AK055546, BC015897, BC016387, BU734789, CA773862, DC377509
    Consensus CDS
    CCDS35057.1
    UniProtKB/Swiss-Prot
    Q5VYS8
    UniProtKB/TrEMBL
    Q96KX5
    Related
    ENSP00000365130.3, ENST00000375963.8
    Conserved Domains (4) summary
    cd05402
    Location:10211138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:14521468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:12331286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:13711450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    86287733..86354497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252207.3XP_005252264.1  terminal uridylyltransferase 7 isoform X6

    See identical proteins and their annotated locations for XP_005252264.1

    Conserved Domains (4) summary
    cd05402
    Location:10211138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:14521468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:12331286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:13711450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
  2. XM_006717283.1XP_006717346.1  terminal uridylyltransferase 7 isoform X2

    Conserved Domains (4) summary
    cd05402
    Location:10211138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:14521468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:12331286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:13711450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
  3. XM_017015131.1XP_016870620.1  terminal uridylyltransferase 7 isoform X4

    UniProtKB/Swiss-Prot
    Q5VYS8
    Conserved Domains (4) summary
    cd05402
    Location:10211138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:14521468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:12331286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:13711450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
  4. XM_017015130.1XP_016870619.1  terminal uridylyltransferase 7 isoform X4

    UniProtKB/Swiss-Prot
    Q5VYS8
    Conserved Domains (4) summary
    cd05402
    Location:10211138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:14521468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:12331286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:13711450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
  5. XM_024447672.1XP_024303440.1  terminal uridylyltransferase 7 isoform X9

    Conserved Domains (4) summary
    smart00343
    Location:741757
    ZnF_C2HC; zinc finger
    pfam13696
    Location:636651
    zf-CCHC_2; Zinc knuckle
    pfam16631
    Location:660739
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    cl27230
    Location:268599
    PAP_assoc; Cid1 family poly A polymerase
  6. XM_011519016.1XP_011517318.1  terminal uridylyltransferase 7 isoform X5

    Conserved Domains (4) summary
    cd05402
    Location:10211138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:14521468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:12331286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:13711450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
  7. XM_011519015.1XP_011517317.1  terminal uridylyltransferase 7 isoform X3

    Conserved Domains (4) summary
    cd05402
    Location:10211138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:14521468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:12331286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:13711450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
  8. XM_011519012.2XP_011517314.1  terminal uridylyltransferase 7 isoform X1

    See identical proteins and their annotated locations for XP_011517314.1

    Conserved Domains (4) summary
    cd05402
    Location:10211138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:14521468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:12331286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:13711450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
  9. XM_011519011.2XP_011517313.1  terminal uridylyltransferase 7 isoform X1

    See identical proteins and their annotated locations for XP_011517313.1

    Conserved Domains (4) summary
    cd05402
    Location:10211138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:14521468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:12331286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:13711450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
  10. XM_011519014.2XP_011517316.1  terminal uridylyltransferase 7 isoform X1

    See identical proteins and their annotated locations for XP_011517316.1

    Conserved Domains (4) summary
    cd05402
    Location:10211138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:14521468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:12331286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:13711450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
  11. XM_011519013.2XP_011517315.1  terminal uridylyltransferase 7 isoform X1

    See identical proteins and their annotated locations for XP_011517315.1

    Conserved Domains (4) summary
    cd05402
    Location:10211138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:14521468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:12331286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:13711450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
  12. XM_024447671.1XP_024303439.1  terminal uridylyltransferase 7 isoform X8

    Conserved Domains (4) summary
    smart00343
    Location:741757
    ZnF_C2HC; zinc finger
    pfam13696
    Location:636651
    zf-CCHC_2; Zinc knuckle
    pfam16631
    Location:660739
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    cl27230
    Location:268599
    PAP_assoc; Cid1 family poly A polymerase
  13. XM_005252208.2XP_005252265.1  terminal uridylyltransferase 7 isoform X7

    Conserved Domains (2) summary
    cd05402
    Location:10211138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam03828
    Location:12331286
    PAP_assoc; Cid1 family poly A polymerase

RNA

  1. XR_001746379.1 RNA Sequence

  2. XR_001746380.1 RNA Sequence

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