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TUT7 terminal uridylyl transferase 7 [ Homo sapiens (human) ]

Gene ID: 79670, updated on 13-Mar-2020

Summary

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Official Symbol
TUT7provided by HGNC
Official Full Name
terminal uridylyl transferase 7provided by HGNC
Primary source
HGNC:HGNC:25817
See related
Ensembl:ENSG00000083223 MIM:613467
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAPD6; TENT3B; ZCCHC6
Expression
Ubiquitous expression in prostate (RPKM 7.8), skin (RPKM 6.8) and 25 other tissues See more
Orthologs
mouse all

Genomic context

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See TUT7 in Genome Data Viewer
Location:
9q21.33
Exon count:
32
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (86287733..86354497, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (88902648..88969402, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene chromosome 9 open reading frame 153 Neighboring gene RN7SK pseudogene 264 Neighboring gene iron-sulfur cluster assembly 1 Neighboring gene ribosomal protein S6 pseudogene 13 Neighboring gene uncharacterized LOC102724080 Neighboring gene RNA, U2 small nuclear 36, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TUT7 catalyzes the uridylation of the 3' end for rapid degradation of histone mRNA. Lackey PE, et al. RNA, 2016 Nov. PMID 27609902, Free PMC Article
  2. Genetic Inactivation of ZCCHC6 Suppresses Interleukin-6 Expression and Reduces the Severity of Experimental Osteoarthritis in Mice. Ansari MY, et al. Arthritis Rheumatol, 2019 Apr. PMID 30302948,
  3. Uridylation by TUT4 and TUT7 marks mRNA for degradation. Lim J, et al. Cell, 2014 Dec 4. PMID 25480299, Free PMC Article
  4. 3' Uridylation Confers miRNAs with Non-canonical Target Repertoires. Yang A, et al. Mol Cell, 2019 Aug 8. PMID 31178353,
  5. The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses. Kozlowski E, et al. PLoS One, 2017. PMID 28665939, Free PMC Article

See all (42) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZCCHC6 (TUT7) was markedly up-regulated in damaged cartilage from human osteoarthritis (OA) patients and from wild-type mice with surgically induced OA.
    Title: Genetic Inactivation of ZCCHC6 Suppresses Interleukin-6 Expression and Reduces the Severity of Experimental Osteoarthritis in Mice.
  2. This tail-U-mediated repression (TUMR) is abolished in cells lacking the uridylation enzymes TUT4 and TUT7, indicating that uridylation alters miRNA function by modulating target recognition. We identified a set of non-canonical targets in human cells that are specifically regulated by uridylated miR-27a.
    Title: 3' Uridylation Confers miRNAs with Non-canonical Target Repertoires.
  3. Uridine residues added by TUT7 in the cytoplasm inhibit initiation of reverse transcription of LINE-1 mRNAs once they are reimported to the nucleus.
    Title: Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s.
  4. Results from a study on gene expression variability markers in early-stage human embryos shows that TUT7 (ZCCHC6) is a putative expression variability marker for the 3-day, 8-cell embryo stage.
    Title: Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
  5. Following an intratracheal challenge with S. pneumoniae, Zcchc6 deficiency led to a modest but significant increase in the expression of select cytokines including IL-6, CXCL1, and CXCL5. These findings were recapitulated in vitro whereby Zcchc6-deficient macrophages exhibited similar increases in cytokine expression due to bacterial stimulation
    Title: The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.
  6. The authors found that TUT4(7) utilize two multidomain functional modules during the switch from either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU).
    Title: Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
  7. Knockdown of 3'hExo also altered the uridylation of histone mRNAs, suggesting that TUT7 and 3'hExo function together in trimming and uridylating histone mRNAs
    Title: TUT7 catalyzes the uridylation of the 3' end for rapid degradation of histone mRNA.
  8. TUT7 generates an oligo-U tail in microRNAs that leads to degradation.
    Title: TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms.
  9. Study identified TUT4 and TUT7 as uridylyl transferases for poly(A)+ mRNAs in humans and delineated in detail the action mechanism and molecular function of uridylation in the mRNA decay pathway.
    Title: Uridylation by TUT4 and TUT7 marks mRNA for degradation.
  10. Study identified TUT7, TUT4, and TUT2 as novel components of the miRNA biogenesis pathway.
    Title: Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp666B142, DKFZp686F119, DKFZp686I1269, DKFZp686C11112

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA uridylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
miRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
uridylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
RNA 3' uridylation IDA
Inferred from Direct Assay
more info
 PubMed 
RNA 3' uridylation ISS
Inferred from Sequence or Structural Similarity
more info
  
RNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
NOT histone mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
miRNA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
negative regulation of transposition, RNA-mediated IDA
Inferred from Direct Assay
more info
 PubMed 
nuclear-transcribed mRNA poly(A) tail shortening TAS
Traceable Author Statement
more info
  
oocyte maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
polyuridylation-dependent mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
pre-miRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
cytosol IDA
Inferred from Direct Assay
more info
  
cytosol TAS
Traceable Author Statement
more info
  
nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
terminal uridylyltransferase 7
Names
PAP associated domain containing 6
TUTase 7
zinc finger CCHC domain-containing protein 6
zinc finger CCHC-type containing 6
zinc finger, CCHC domain containing 6
NP_001171988.1
NP_001172003.1
NP_001317647.1
NP_078893.2
XP_005252264.1
XP_005252265.1
XP_006717346.1
XP_011517313.1
XP_011517314.1
XP_011517315.1
XP_011517316.1
XP_011517317.1
XP_011517318.1
XP_016870619.1
XP_016870620.1
XP_024303439.1
XP_024303440.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185059.2 → NP_001171988.1  terminal uridylyltransferase 7 isoform 1

    See identical proteins and their annotated locations for NP_001171988.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein isoform.
    Source sequence(s)
    AK055546, AK055948, BC015897, CR933643
    Consensus CDS
    CCDS35057.1
    UniProtKB/Swiss-Prot
    Q5VYS8
    Conserved Domains (4) summary
    cd05402
    Location:1021 → 1138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:1452 → 1468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:1233 → 1286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1371 → 1450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

  2. NM_001185074.2 → NP_001172003.1  terminal uridylyltransferase 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two different regions of sequence, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK055546, AL832026, BC015897, BU734789, CA773862
    Consensus CDS
    CCDS55323.1
    UniProtKB/Swiss-Prot
    Q5VYS8
    Related
    ENSP00000365127.2, ENST00000375960.6
    Conserved Domains (5) summary
    cd05402
    Location:830 → 902
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:1216 → 1232
    ZnF_C2HC; zinc finger
    pfam03828
    Location:997 → 1050
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1135 → 1214
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    cl11966
    Location:315 → 360
    NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins

  3. NM_001330718.2 → NP_001317647.1  terminal uridylyltransferase 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK055948, AL137849, AL353678, CN419677, CR933643, CR933644, DB156789
    Consensus CDS
    CCDS83383.1
    UniProtKB/Swiss-Prot
    Q5VYS8
    UniProtKB/TrEMBL
    X6R3Q3
    Related
    ENSP00000277141.6, ENST00000277141.10

  4. NM_024617.4 → NP_078893.2  terminal uridylyltransferase 7 isoform 1

    See identical proteins and their annotated locations for NP_078893.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein isoform.
    Source sequence(s)
    AK055546, BC015897, BC016387, BU734789, CA773862, DC377509
    Consensus CDS
    CCDS35057.1
    UniProtKB/Swiss-Prot
    Q5VYS8
    UniProtKB/TrEMBL
    Q96KX5
    Related
    ENSP00000365130.3, ENST00000375963.8
    Conserved Domains (4) summary
    cd05402
    Location:1021 → 1138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:1452 → 1468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:1233 → 1286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1371 → 1450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    86287733..86354497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252207.3 → XP_005252264.1  terminal uridylyltransferase 7 isoform X6

    See identical proteins and their annotated locations for XP_005252264.1

    Conserved Domains (4) summary
    cd05402
    Location:1021 → 1138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:1452 → 1468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:1233 → 1286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1371 → 1450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

  2. XM_006717283.1 → XP_006717346.1  terminal uridylyltransferase 7 isoform X2

    Conserved Domains (4) summary
    cd05402
    Location:1021 → 1138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:1452 → 1468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:1233 → 1286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1371 → 1450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

  3. XM_017015131.1 → XP_016870620.1  terminal uridylyltransferase 7 isoform X4

    UniProtKB/Swiss-Prot
    Q5VYS8
    Conserved Domains (4) summary
    cd05402
    Location:1021 → 1138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:1452 → 1468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:1233 → 1286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1371 → 1450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

  4. XM_017015130.1 → XP_016870619.1  terminal uridylyltransferase 7 isoform X4

    UniProtKB/Swiss-Prot
    Q5VYS8
    Conserved Domains (4) summary
    cd05402
    Location:1021 → 1138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:1452 → 1468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:1233 → 1286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1371 → 1450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

  5. XM_024447672.1 → XP_024303440.1  terminal uridylyltransferase 7 isoform X9

    Conserved Domains (4) summary
    smart00343
    Location:741 → 757
    ZnF_C2HC; zinc finger
    pfam13696
    Location:636 → 651
    zf-CCHC_2; Zinc knuckle
    pfam16631
    Location:660 → 739
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    cl27230
    Location:268 → 599
    PAP_assoc; Cid1 family poly A polymerase

  6. XM_011519016.1 → XP_011517318.1  terminal uridylyltransferase 7 isoform X5

    Conserved Domains (4) summary
    cd05402
    Location:1021 → 1138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:1452 → 1468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:1233 → 1286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1371 → 1450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

  7. XM_011519015.1 → XP_011517317.1  terminal uridylyltransferase 7 isoform X3

    Conserved Domains (4) summary
    cd05402
    Location:1021 → 1138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:1452 → 1468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:1233 → 1286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1371 → 1450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

  8. XM_011519012.2 → XP_011517314.1  terminal uridylyltransferase 7 isoform X1

    See identical proteins and their annotated locations for XP_011517314.1

    Conserved Domains (4) summary
    cd05402
    Location:1021 → 1138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:1452 → 1468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:1233 → 1286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1371 → 1450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

  9. XM_011519011.2 → XP_011517313.1  terminal uridylyltransferase 7 isoform X1

    See identical proteins and their annotated locations for XP_011517313.1

    Conserved Domains (4) summary
    cd05402
    Location:1021 → 1138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:1452 → 1468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:1233 → 1286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1371 → 1450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

  10. XM_011519014.2 → XP_011517316.1  terminal uridylyltransferase 7 isoform X1

    See identical proteins and their annotated locations for XP_011517316.1

    Conserved Domains (4) summary
    cd05402
    Location:1021 → 1138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:1452 → 1468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:1233 → 1286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1371 → 1450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

  11. XM_011519013.2 → XP_011517315.1  terminal uridylyltransferase 7 isoform X1

    See identical proteins and their annotated locations for XP_011517315.1

    Conserved Domains (4) summary
    cd05402
    Location:1021 → 1138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    smart00343
    Location:1452 → 1468
    ZnF_C2HC; zinc finger
    pfam03828
    Location:1233 → 1286
    PAP_assoc; Cid1 family poly A polymerase
    pfam16631
    Location:1371 → 1450
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

  12. XM_024447671.1 → XP_024303439.1  terminal uridylyltransferase 7 isoform X8

    Conserved Domains (4) summary
    smart00343
    Location:741 → 757
    ZnF_C2HC; zinc finger
    pfam13696
    Location:636 → 651
    zf-CCHC_2; Zinc knuckle
    pfam16631
    Location:660 → 739
    TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    cl27230
    Location:268 → 599
    PAP_assoc; Cid1 family poly A polymerase

  13. XM_005252208.2 → XP_005252265.1  terminal uridylyltransferase 7 isoform X7

    Conserved Domains (2) summary
    cd05402
    Location:1021 → 1138
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam03828
    Location:1233 → 1286
    PAP_assoc; Cid1 family poly A polymerase

RNA

  1. XR_001746379.1 RNA Sequence

  2. XR_001746380.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VYS8.1 GenPept UniProtKB/Swiss-Prot:Q5VYS8

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