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PARP8 poly(ADP-ribose) polymerase family member 8 [ Homo sapiens (human) ]

Gene ID: 79668, updated on 3-Jun-2019

Summary

Official Symbol
PARP8provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 8provided by HGNC
Primary source
HGNC:HGNC:26124
See related
Ensembl:ENSG00000151883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARTD16; pART16
Expression
Broad expression in bone marrow (RPKM 11.4), thyroid (RPKM 9.6) and 24 other tissues See more
Orthologs

Genomic context

See PARP8 in Genome Data Viewer
Location:
5q11.1
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (50665831..50846522)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (49961733..50142356)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene embigin Neighboring gene peptidylprolyl isomerase A like 4G pseudogene Neighboring gene long intergenic non-protein coding RNA 2106 Neighboring gene conserved regulatory element of the islet-1 gene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genetic variants on chromosome 1q41 influence ocular axial length and high myopia.
NHGRI GWA Catalog
Genetics of callous-unemotional behavior in children.
NHGRI GWA Catalog

Pathways from BioSystems

  • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
    Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
  • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
    Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, classified according to their solubility, either fat-soluble or water-soluble, that are either not synthesized or synthesized only in limited amount...
  • Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of water-soluble vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only ...
  • Nicotinamide salvaging, organism-specific biosystem (from REACTOME)
    Nicotinamide salvaging, organism-specific biosystemNicotinamide (NAM) levels are modulated by the action of three enzymes involved in nicotinamide salvaging. They are nicotinamide deaminase, nicotinamide phosphoribosyltransferase and nicotinate phosp...
  • Nicotinate metabolism, organism-specific biosystem (from REACTOME)
    Nicotinate metabolism, organism-specific biosystemNicotinate (niacin) and nicotinamide are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). When NAD+ and NADP+ are intercha...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21308, MGC42864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ADP-ribosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
protein ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein mono-ADP-ribosyltransferase PARP8; poly [ADP-ribose] polymerase 8
Names
ADP-ribosyltransferase diphtheria toxin-like 16
NP_001171526.1
NP_001171527.1
NP_001317957.1
NP_078891.2
XP_005248653.1
XP_011541933.1
XP_011541934.2
XP_011541935.2
XP_011541936.1
XP_011541937.1
XP_011541938.1
XP_011541942.1
XP_011541943.1
XP_011541944.1
XP_011541945.1
XP_016865340.1
XP_024301974.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001178055.2NP_001171526.1  protein mono-ADP-ribosyltransferase PARP8 isoform 1

    See identical proteins and their annotated locations for NP_001171526.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC022441, AK314466, AL834477, DC429180
    Consensus CDS
    CCDS3954.1
    UniProtKB/Swiss-Prot
    Q8N3A8
    UniProtKB/TrEMBL
    B2RB27
    Related
    ENSP00000422217.2, ENST00000505697.6
    Conserved Domains (1) summary
    cd01341
    Location:694818
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  2. NM_001178056.2NP_001171527.1  protein mono-ADP-ribosyltransferase PARP8 isoform 2

    See identical proteins and their annotated locations for NP_001171527.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC022441, AC112187, BC075801, DC417471, DC429180
    Consensus CDS
    CCDS54849.1
    UniProtKB/Swiss-Prot
    Q8N3A8
    Related
    ENSP00000424814.2, ENST00000514067.6
    Conserved Domains (2) summary
    cd01341
    Location:652776
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    cl00283
    Location:482563
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  3. NM_001331028.2NP_001317957.1  protein mono-ADP-ribosyltransferase PARP8 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5'-terminal exon and an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC008919, AC022441, AC112187
    Consensus CDS
    CCDS82996.1
    UniProtKB/TrEMBL
    E9PFI7
    Related
    ENSP00000423946.1, ENST00000505554.5
  4. NM_024615.4NP_078891.2  protein mono-ADP-ribosyltransferase PARP8 isoform 1

    See identical proteins and their annotated locations for NP_078891.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC022441, AC112187, AL834477, DC417471, DC429180
    Consensus CDS
    CCDS3954.1
    UniProtKB/Swiss-Prot
    Q8N3A8
    Related
    ENSP00000281631.4, ENST00000281631.10
    Conserved Domains (1) summary
    cd01341
    Location:694818
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    50665831..50846522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446206.1XP_024301974.1  poly [ADP-ribose] polymerase 8 isoform X6

    Conserved Domains (1) summary
    cd01341
    Location:500624
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  2. XM_011543635.2XP_011541937.1  poly [ADP-ribose] polymerase 8 isoform X5

    See identical proteins and their annotated locations for XP_011541937.1

    Conserved Domains (1) summary
    cd01341
    Location:634758
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  3. XM_011543631.3XP_011541933.1  poly [ADP-ribose] polymerase 8 isoform X2

    See identical proteins and their annotated locations for XP_011541933.1

    UniProtKB/Swiss-Prot
    Q8N3A8
    Conserved Domains (1) summary
    cd01341
    Location:694818
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  4. XM_011543641.2XP_011541943.1  poly [ADP-ribose] polymerase 8 isoform X6

    See identical proteins and their annotated locations for XP_011541943.1

    Conserved Domains (1) summary
    cd01341
    Location:500624
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  5. XM_005248596.5XP_005248653.1  poly [ADP-ribose] polymerase 8 isoform X1

    Conserved Domains (1) summary
    cd01341
    Location:735859
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  6. XM_011543632.3XP_011541934.2  poly [ADP-ribose] polymerase 8 isoform X3

    UniProtKB/Swiss-Prot
    Q8N3A8
    Conserved Domains (2) summary
    cd01341
    Location:652776
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    cl00283
    Location:482563
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  7. XM_011543633.3XP_011541935.2  poly [ADP-ribose] polymerase 8 isoform X4

  8. XM_011543634.2XP_011541936.1  poly [ADP-ribose] polymerase 8 isoform X5

    See identical proteins and their annotated locations for XP_011541936.1

    Conserved Domains (1) summary
    cd01341
    Location:634758
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  9. XM_011543643.2XP_011541945.1  poly [ADP-ribose] polymerase 8 isoform X6

    See identical proteins and their annotated locations for XP_011541945.1

    Conserved Domains (1) summary
    cd01341
    Location:500624
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  10. XM_017009851.1XP_016865340.1  poly [ADP-ribose] polymerase 8 isoform X7

    Related
    ENSP00000439022.1, ENST00000514342.6
    Conserved Domains (1) summary
    cd01341
    Location:447571
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  11. XM_011543642.2XP_011541944.1  poly [ADP-ribose] polymerase 8 isoform X6

    See identical proteins and their annotated locations for XP_011541944.1

    Conserved Domains (1) summary
    cd01341
    Location:500624
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  12. XM_011543640.3XP_011541942.1  poly [ADP-ribose] polymerase 8 isoform X6

    See identical proteins and their annotated locations for XP_011541942.1

    Conserved Domains (1) summary
    cd01341
    Location:500624
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  13. XM_011543636.2XP_011541938.1  poly [ADP-ribose] polymerase 8 isoform X5

    See identical proteins and their annotated locations for XP_011541938.1

    Conserved Domains (1) summary
    cd01341
    Location:634758
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

RNA

  1. XR_002956178.1 RNA Sequence

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