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NEIL1 nei like DNA glycosylase 1 [ Homo sapiens (human) ]

Gene ID: 79661, updated on 5-Jan-2022

Summary

Official Symbol
NEIL1provided by HGNC
Official Full Name
nei like DNA glycosylase 1provided by HGNC
Primary source
HGNC:HGNC:18448
See related
Ensembl:ENSG00000140398 MIM:608844
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FPG1; NEI1; hFPG1
Summary
This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in lymph node (RPKM 8.2), bone marrow (RPKM 5.5) and 25 other tissues See more
Orthologs
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Genomic context

See NEIL1 in Genome Data Viewer
Location:
15q24.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (75347039..75357115)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75639380..75649456)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene acidic nuclear phosphoprotein 32 family member B pseudogene 1 Neighboring gene COMM domain containing 4 Neighboring gene Sharpr-MPRA regulatory region 1822 Neighboring gene microRNA 631 Neighboring gene mannosidase alpha class 2C member 1 Neighboring gene Sharpr-MPRA regulatory region 58 Neighboring gene SIN3 transcription regulator family member A Neighboring gene ribosomal protein L13 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22402

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA N-glycosylase activity TAS
Traceable Author Statement
more info
 
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-(apurinic or apyrimidinic site) endonuclease activity TAS
Traceable Author Statement
more info
 
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IDA
Inferred from Direct Assay
more info
PubMed 
enables protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in base-excision repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in base-excision repair, gap-filling TAS
Traceable Author Statement
more info
 
involved_in depyrimidination TAS
Traceable Author Statement
more info
 
involved_in negative regulation of nuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
endonuclease 8-like 1
Names
DNA endonuclease eight-like glycosylase 1
DNA glycosylase/AP lyase Neil1
DNA-(apurinic or apyrimidinic site) lyase Neil1
NEH1
endonuclease VIII
endonuclease VIII-like 1
nei endonuclease VIII-like 1
nei homolog 1
nei-like protein 1
NP_001243481.1
NP_001339448.1
NP_001339449.1
NP_078884.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256552.1NP_001243481.1  endonuclease 8-like 1 isoform 1

    See identical proteins and their annotated locations for NP_001243481.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC068338, BC010876
    UniProtKB/Swiss-Prot
    Q96FI4
    Conserved Domains (3) summary
    cd08967
    Location:87213
    MeNeil1_N; N-terminal domain of metazoan Nei-like glycosylase 1 (NEIL1)
    pfam06831
    Location:245283
    H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain
    pfam09292
    Location:338376
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
  2. NM_001352519.2NP_001339448.1  endonuclease 8-like 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC068338
    Conserved Domains (1) summary
    cl26942
    Location:86179
    H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain
  3. NM_001352520.2NP_001339449.1  endonuclease 8-like 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC068338
    Conserved Domains (3) summary
    pfam09292
    Location:150188
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cl03119
    Location:137
    FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases
    cl26942
    Location:44112
    H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain
  4. NM_024608.4NP_078884.2  endonuclease 8-like 1 isoform 2

    See identical proteins and their annotated locations for NP_078884.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB079068, AC068338, AK026055, DB282730
    Consensus CDS
    CCDS10278.1
    UniProtKB/Swiss-Prot
    Q96FI4
    Related
    ENSP00000347170.4, ENST00000355059.9
    Conserved Domains (3) summary
    cd08967
    Location:1127
    MeNeil1_N; N-terminal domain of metazoan Nei-like glycosylase 1 (NEIL1)
    PRK10445
    Location:134194
    PRK10445; endonuclease VIII; Provisional
    pfam09292
    Location:252290
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind

RNA

  1. NR_046311.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC068338, AK097008

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    75347039..75357115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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