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PPP1R3B protein phosphatase 1 regulatory subunit 3B [ Homo sapiens (human) ]

Gene ID: 79660, updated on 4-May-2020

Summary

Official Symbol
PPP1R3Bprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 3Bprovided by HGNC
Primary source
HGNC:HGNC:14942
See related
Ensembl:ENSG00000173281 MIM:610541
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GL; PTG; PPP1R4
Summary
This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011]
Expression
Broad expression in liver (RPKM 50.1), heart (RPKM 12.4) and 22 other tissues See more
Orthologs

Genomic context

See PPP1R3B in Genome Data Viewer
Location:
8p23.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (9136255..9151586, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (8993764..9009152, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene exoribonuclease 1 Neighboring gene small nucleolar RNA, C/D box 3I Neighboring gene RNA, U7 small nuclear 55 pseudogene Neighboring gene uncharacterized LOC102724880 Neighboring gene uncharacterized LOC101929128

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
NHGRI GWA Catalog
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
NHGRI GWA Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
NHGRI GWA Catalog
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
NHGRI GWA Catalog
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog
Genome-wide association study of Alzheimer's disease.
NHGRI GWA Catalog
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
NHGRI GWA Catalog
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
NHGRI GWA Catalog
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
NHGRI GWA Catalog
Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
NHGRI GWA Catalog
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of protein phosphatase 1, regulatory subunit 3B (PPP1R3B) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14005, FLJ34675

Gene Ontology Provided by GOA

Function Evidence Code Pubs
[phosphorylase] phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
glycogen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of glycogen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
glycogen granule IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 1 complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 3B
Names
PP1 subunit R4
hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL
hepatic glycogen-targeting subunit, G(L)
protein phosphatase 1 regulatory subunit 4
protein phosphatase 1, regulatory (inhibitor) subunit 3B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028089.1 RefSeqGene

    Range
    5104..20388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201329.2NP_001188258.1  protein phosphatase 1 regulatory subunit 3B

    See identical proteins and their annotated locations for NP_001188258.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC022784, AI263711, BQ431880, DB282578
    Consensus CDS
    CCDS5973.1
    UniProtKB/Swiss-Prot
    Q86XI6
    Related
    ENSP00000428642.1, ENST00000519699.1
    Conserved Domains (1) summary
    pfam03370
    Location:127232
    CBM_21; Carbohydrate/starch-binding module (family 21)
  2. NM_024607.4NP_078883.2  protein phosphatase 1 regulatory subunit 3B

    See identical proteins and their annotated locations for NP_078883.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC022784, AI263711, BQ431880, DA100998
    Consensus CDS
    CCDS5973.1
    UniProtKB/Swiss-Prot
    Q86XI6
    Related
    ENSP00000308318.3, ENST00000310455.4
    Conserved Domains (1) summary
    pfam03370
    Location:127232
    CBM_21; Carbohydrate/starch-binding module (family 21)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    9136255..9151586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013835.1XP_016869324.1  protein phosphatase 1 regulatory subunit 3B isoform X1

    UniProtKB/Swiss-Prot
    Q86XI6
    Conserved Domains (1) summary
    pfam03370
    Location:127232
    CBM_21; Carbohydrate/starch-binding module (family 21)
  2. XM_006716253.3XP_006716316.1  protein phosphatase 1 regulatory subunit 3B isoform X1

    See identical proteins and their annotated locations for XP_006716316.1

    UniProtKB/Swiss-Prot
    Q86XI6
    Conserved Domains (1) summary
    pfam03370
    Location:127232
    CBM_21; Carbohydrate/starch-binding module (family 21)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p13 PATCHES

    Range
    4200090..4215375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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