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PPP1R3B protein phosphatase 1 regulatory subunit 3B [ Homo sapiens (human) ]

Gene ID: 79660, updated on 17-Sep-2022

Summary

Official Symbol
PPP1R3Bprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 3Bprovided by HGNC
Primary source
HGNC:HGNC:14942
See related
Ensembl:ENSG00000173281 MIM:610541; AllianceGenome:HGNC:14942
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GL; PTG; PPP1R4
Summary
This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011]
Expression
Broad expression in liver (RPKM 50.1), heart (RPKM 12.4) and 22 other tissues See more
Orthologs
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Genomic context

See PPP1R3B in Genome Data Viewer
Location:
8p23.1
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (9136255..9151539, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (10592540..10607824)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (8993765..9009049, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene exoribonuclease 1 Neighboring gene RNA, U7 small nuclear 55 pseudogene Neighboring gene uncharacterized LOC112268402 Neighboring gene Sharpr-MPRA regulatory region 9732 Neighboring gene uncharacterized LOC124901882 Neighboring gene PPP1R3B divergent transcript Neighboring gene uncharacterized LOC101929128

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
EBI GWAS Catalog
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
EBI GWAS Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
EBI GWAS Catalog
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
EBI GWAS Catalog
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog
Genome-wide association study of Alzheimer's disease.
EBI GWAS Catalog
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
EBI GWAS Catalog
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
EBI GWAS Catalog
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
EBI GWAS Catalog
Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
EBI GWAS Catalog
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of protein phosphatase 1, regulatory subunit 3B (PPP1R3B) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14005, FLJ34675

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables [phosphorylase] phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables glycogen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of glycogen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in glycogen granule IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
part_of protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 3B
Names
PP1 subunit R4
hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL
hepatic glycogen-targeting subunit, G(L)
protein phosphatase 1 regulatory subunit 4
protein phosphatase 1, regulatory (inhibitor) subunit 3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028089.1 RefSeqGene

    Range
    5985..20388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201329.2NP_001188258.1  protein phosphatase 1 regulatory subunit 3B

    See identical proteins and their annotated locations for NP_001188258.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC022784, AI263711, BQ431880, DB282578
    Consensus CDS
    CCDS5973.1
    UniProtKB/Swiss-Prot
    Q86XI6, Q9H812
    Related
    ENSP00000428642.1, ENST00000519699.1
    Conserved Domains (1) summary
    pfam03370
    Location:127232
    CBM_21; Carbohydrate/starch-binding module (family 21)
  2. NM_024607.4NP_078883.2  protein phosphatase 1 regulatory subunit 3B

    See identical proteins and their annotated locations for NP_078883.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC022784, AI263711, BQ431880, DA100998
    Consensus CDS
    CCDS5973.1
    UniProtKB/Swiss-Prot
    Q86XI6, Q9H812
    Related
    ENSP00000308318.3, ENST00000310455.4
    Conserved Domains (1) summary
    pfam03370
    Location:127232
    CBM_21; Carbohydrate/starch-binding module (family 21)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    9136255..9151539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422235.1XP_047278191.1  protein phosphatase 1 regulatory subunit 3B isoform X1

    UniProtKB/Swiss-Prot
    Q9H812
  2. XM_006716253.4XP_006716316.1  protein phosphatase 1 regulatory subunit 3B isoform X1

    See identical proteins and their annotated locations for XP_006716316.1

    UniProtKB/Swiss-Prot
    Q86XI6, Q9H812
    Conserved Domains (1) summary
    pfam03370
    Location:127232
    CBM_21; Carbohydrate/starch-binding module (family 21)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    4200090..4215375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    10592540..10607824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)