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AIMP2 aminoacyl tRNA synthetase complex interacting multifunctional protein 2 [ Homo sapiens (human) ]

Gene ID: 7965, updated on 7-Jun-2020

Summary

Official Symbol
AIMP2provided by HGNC
Official Full Name
aminoacyl tRNA synthetase complex interacting multifunctional protein 2provided by HGNC
Primary source
HGNC:HGNC:20609
See related
Ensembl:ENSG00000106305 MIM:600859
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P38; JTV1; HLD17; JTV-1
Summary
The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]
Expression
Ubiquitous expression in testis (RPKM 18.6), duodenum (RPKM 17.0) and 25 other tissues See more
Orthologs

Genomic context

See AIMP2 in Genome Data Viewer
Location:
7p22.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (6009245..6023834)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6048882..6063465)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CCZ1 homolog, vacuolar protein trafficking and biogenesis associated Neighboring gene radial spoke head 10 homolog B Neighboring gene PMS1 homolog 2, mismatch repair system component Neighboring gene small nucleolar RNA, H/ACA box 80D Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene ankyrin repeat domain 61 Neighboring gene RNA, 7SL, cytoplasmic 851, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) is identified in a series of six affinity purification/mass spectrometry screens PubMed
matrix gag HIV-1 MA is identified to have a physical interaction with aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of aminoacyl-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
tRNA aminoacylation for protein translation TAS
Traceable Author Statement
more info
 
type II pneumocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Names
ARS-interacting multi-functional protein 2
multisynthase complex auxiliary component p38
multisynthetase complex auxiliary component p38
protein JTV-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050738.1 RefSeqGene

    Range
    5022..19584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001326606.1NP_001313535.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of the first exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC005995, CX867709
    Conserved Domains (1) summary
    cd03200
    Location:174269
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  2. NM_001326607.1NP_001313536.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC005995
    Consensus CDS
    CCDS87475.1
    UniProtKB/TrEMBL
    F8W950
    Related
    ENSP00000378658.2, ENST00000395236.2
  3. NM_001326609.1NP_001313538.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
    Source sequence(s)
    AC005995
    Consensus CDS
    CCDS87476.1
    UniProtKB/TrEMBL
    A8MU58
    Conserved Domains (1) summary
    cd03200
    Location:136231
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  4. NM_001326610.1NP_001313539.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
    Source sequence(s)
    AC005995
    Consensus CDS
    CCDS87476.1
    UniProtKB/TrEMBL
    A8MU58
    Related
    ENSP00000383327.2, ENST00000400479.6
    Conserved Domains (1) summary
    cd03200
    Location:136231
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  5. NM_001326611.2NP_001313540.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
    Source sequence(s)
    AC005995, AI479424, AW131494, CB152528, CX756571
    Consensus CDS
    CCDS87476.1
    UniProtKB/TrEMBL
    A8MU58
    Conserved Domains (1) summary
    cd03200
    Location:136231
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  6. NM_001362785.1NP_001349714.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC005995, AI479424, AW131494, CX756571
    Conserved Domains (1) summary
    cd03200
    Location:185280
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  7. NM_001362787.1NP_001349716.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC005995, AI479424, AW131494, CX756571
    Conserved Domains (1) summary
    cd03200
    Location:170265
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  8. NM_006303.4NP_006294.2  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform a

    See identical proteins and their annotated locations for NP_006294.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC005995, BC002853
    Consensus CDS
    CCDS5344.1
    UniProtKB/Swiss-Prot
    Q13155
    UniProtKB/TrEMBL
    A0A024QZY1
    Related
    ENSP00000223029.3, ENST00000223029.8
    Conserved Domains (2) summary
    cd03200
    Location:214309
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
    pfam16780
    Location:133
    AIMP2_LysRS_bd; AIMP2 lysyl-tRNA synthetase binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    6009245..6023834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249847.3XP_005249904.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X1

    Conserved Domains (1) summary
    cd03200
    Location:207302
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018570.1: Suppressed sequence

    Description
    NM_018570.1: This RefSeq was removed because it is primarily UTR sequence.
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