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AIMP2 aminoacyl tRNA synthetase complex interacting multifunctional protein 2 [ Homo sapiens (human) ]

Gene ID: 7965, updated on 6-Dec-2016
Official Symbol
AIMP2provided by HGNC
Official Full Name
aminoacyl tRNA synthetase complex interacting multifunctional protein 2provided by HGNC
Primary source
HGNC:HGNC:20609
See related
Ensembl:ENSG00000106305 MIM:600859; Vega:OTTHUMG00000122077
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P38; JTV1; JTV-1
Summary
The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]
Orthologs
Location:
7p22.1
Exon count:
8
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (6009241..6023834)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6048882..6063465)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene radial spoke head 10 homolog B Neighboring gene PMS1 homolog 2, mismatch repair system component Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene ankyrin repeat domain 61 Neighboring gene RNA, 7SL, cytoplasmic 851, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) is identified in a series of six affinity purification/mass spectrometry screens PubMed
matrix gag HIV-1 MA is identified to have a physical interaction with aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

  • Cytosolic tRNA aminoacylation, organism-specific biosystem (from REACTOME)
    Cytosolic tRNA aminoacylation, organism-specific biosystemCytosolic tRNA synthetases catalyze the reactions of tRNAs encoded in the nuclear genome, their cognate amino acids, and ATP to form aminoacyl-tRNAs, AMP, and pyrophosphate. Eight of the tRNA synthet...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
  • Osteoclast Signaling, organism-specific biosystem (from WikiPathways)
    Osteoclast Signaling, organism-specific biosystem
    Osteoclast Signaling
  • SeMet incorporation into proteins, organism-specific biosystem (from REACTOME)
    SeMet incorporation into proteins, organism-specific biosystemAs a first step in the incorporation of selenomethionine into proteins, tRNA(Met) is converted into selenomethionyl-tRNA(Met) (SeMet-tRNA(Met)) by methionine-tRNA ligase (MARS) component of a multisy...
  • Selenoamino acid metabolism, organism-specific biosystem (from REACTOME)
    Selenoamino acid metabolism, organism-specific biosystemSelenium (Se) is a trace element essential for the normal function of the body. Selenoamino acids are defined as those amino acids where selenium has been substituted for sulphur. Selenium and sulp...
  • Transcriptional activation by NRF2, organism-specific biosystem (from WikiPathways)
    Transcriptional activation by NRF2, organism-specific biosystemBased on [http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html Surh, 2003, figure 4]. Nrf2 induces the expression of many antioxidant enzymes. It is therefore thought to be involved in ox...
  • tRNA Aminoacylation, organism-specific biosystem (from REACTOME)
    tRNA Aminoacylation, organism-specific biosystemtRNA synthetases catalyze the ligation of tRNAs to their cognate amino acids in an ATP-dependent manner. The reaction proceeds in two steps. First, amino acid and ATP form an aminoacyl adenylate mole...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Type II pneumocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
tRNA aminoacylation for protein translation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Names
ARS-interacting multi-functional protein 2
multisynthase complex auxiliary component p38
multisynthetase complex auxiliary component p38
protein JTV-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050738.1 RefSeqGene

    Range
    5001..19584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001326606.1NP_001313535.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of the first exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC005995, CX867709
    Conserved Domains (1) summary
    cd03200
    Location:174269
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  2. NM_001326607.1NP_001313536.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC005995
    UniProtKB/TrEMBL
    F8W950
  3. NM_001326609.1NP_001313538.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
    Source sequence(s)
    AC005995
    UniProtKB/TrEMBL
    A8MU58
    Conserved Domains (1) summary
    cd03200
    Location:136231
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  4. NM_001326610.1NP_001313539.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
    Source sequence(s)
    AC005995
    UniProtKB/TrEMBL
    A8MU58
    Conserved Domains (1) summary
    cd03200
    Location:136231
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  5. NM_001326611.1NP_001313540.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
    Source sequence(s)
    AC005995
    UniProtKB/TrEMBL
    A8MU58
    Conserved Domains (1) summary
    cd03200
    Location:136231
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  6. NM_006303.3NP_006294.2  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform a

    See identical proteins and their annotated locations for NP_006294.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC005995, BC002853
    Consensus CDS
    CCDS5344.1
    UniProtKB/Swiss-Prot
    Q13155
    UniProtKB/TrEMBL
    A0A024QZY1
    Related
    ENSP00000223029, OTTHUMP00000151158, ENST00000223029, OTTHUMT00000242834
    Conserved Domains (2) summary
    cd03200
    Location:214309
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
    pfam16780
    Location:133
    AIMP2_LysRS_bd; AIMP2 lysyl-tRNA synthetase binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

    Range
    6009241..6023834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249848.2XP_005249905.1  

    Conserved Domains (1) summary
    cd03200
    Location:174269
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  2. XM_006715772.2XP_006715835.1  

    Conserved Domains (1) summary
    cd03200
    Location:170265
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  3. XM_005249850.3XP_005249907.1  

    UniProtKB/TrEMBL
    A8MU58
    Related
    ENSP00000383327, OTTHUMP00000201310, ENST00000400479, OTTHUMT00000325473
    Conserved Domains (1) summary
    cd03200
    Location:136231
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  4. XM_011515519.1XP_011513821.1  

    Conserved Domains (1) summary
    cd03200
    Location:185280
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  5. XM_005249847.3XP_005249904.1  

    Conserved Domains (1) summary
    cd03200
    Location:207302
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    6048601..6063172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018570.1: Suppressed sequence

    Description
    NM_018570.1: This RefSeq was removed because it is primarily UTR sequence.
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