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AKIRIN1 akirin 1 [ Homo sapiens (human) ]

Gene ID: 79647, updated on 22-Sep-2022

Summary

Official Symbol
AKIRIN1provided by HGNC
Official Full Name
akirin 1provided by HGNC
Primary source
HGNC:HGNC:25744
See related
Ensembl:ENSG00000174574 MIM:615164; AllianceGenome:HGNC:25744
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STRF2; C1orf108
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in several processes, including myoblast migration involved in skeletal muscle regeneration; negative regulation of satellite cell differentiation; and positive regulation of lamellipodium assembly. Located in nuclear membrane and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 41.1), bone marrow (RPKM 25.3) and 25 other tissues See more
Orthologs
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Genomic context

See AKIRIN1 in Genome Data Viewer
Location:
1p34.3
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (38991276..39006059)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (38858494..38873280)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (39456948..39471731)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene rhomboid like 2 Neighboring gene RNA, U6 small nuclear 605, pseudogene Neighboring gene eukaryotic translation initiation factor 1 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 593 Neighboring gene uncharacterized LOC124904088 Neighboring gene NADH:ubiquinone oxidoreductase subunit S5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12666

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in myoblast migration involved in skeletal muscle regeneration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in myoblast migration involved in skeletal muscle regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of satellite cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of skeletal muscle satellite cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of skeletal muscle satellite cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of lamellipodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of macrophage chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of myoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136275.2NP_001129747.1  akirin-1 isoform 2

    See identical proteins and their annotated locations for NP_001129747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK303098, AL606465, DB727813
    Consensus CDS
    CCDS44113.1
    UniProtKB/Swiss-Prot
    Q9H9L7
    Related
    ENSP00000389866.2, ENST00000446189.6
  2. NM_024595.3NP_078871.1  akirin-1 isoform 1

    See identical proteins and their annotated locations for NP_078871.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL606465, BC119745, DB727813
    Consensus CDS
    CCDS433.1
    UniProtKB/Swiss-Prot
    Q53FK8, Q9H9L7
    Related
    ENSP00000392678.3, ENST00000432648.8
    Conserved Domains (1) summary
    cd22243
    Location:2192
    akirin-1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    38991276..39006059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    38858494..38873280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)