U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CHMP6 charged multivesicular body protein 6 [ Homo sapiens (human) ]

Gene ID: 79643, updated on 1-Oct-2024

Summary

Official Symbol
CHMP6provided by HGNC
Official Full Name
charged multivesicular body protein 6provided by HGNC
Primary source
HGNC:HGNC:25675
See related
Ensembl:ENSG00000176108 MIM:610901; AllianceGenome:HGNC:25675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VPS20
Summary
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in biosynthesis of endosomes. [provided by RefSeq, Mar 2012]
Expression
Ubiquitous expression in kidney (RPKM 3.0), colon (RPKM 3.0) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CHMP6 in Genome Data Viewer
Location:
17q25.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (80991841..81000133)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (81898759..81907012)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (78965641..78973933)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene regulatory associated protein of MTOR complex 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78943614-78944419 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78944420-78945224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78955555-78956054 Neighboring gene uncharacterized LOC400627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9114 Neighboring gene ribosomal protein L12 pseudogene 37 Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC124904078

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag A fragment (amino acids 1-167) of CHMP6 is a potent dominant negative inhibitor of HIV-1 Gag release from cells PubMed
gag Budding of HIV-1 Gag with a PTAP point mutation is rescued by fusion to an ESCRT-III protein, CHMP6 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ11749

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in ESCRT III complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in late endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in macroautophagy TAS
Traceable Author Statement
more info
PubMed 
involved_in membrane fission NAS
Non-traceable Author Statement
more info
PubMed 
involved_in midbody abscission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multivesicular body assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in multivesicular body assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in multivesicular body sorting pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in multivesicular body-lysosome fusion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear membrane reassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleus organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plasma membrane repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in regulation of exosomal secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle budding from membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vesicle fusion with vacuole NAS
Non-traceable Author Statement
more info
PubMed 
involved_in viral budding from plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in viral budding via host ESCRT complex IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of ESCRT III complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ESCRT III complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ESCRT III complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of ESCRT III complex TAS
Traceable Author Statement
more info
PubMed 
located_in amphisome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in autophagosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in multivesicular body membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
charged multivesicular body protein 6
Names
chromatin-modifying protein 6
hVps20
vacuolar protein sorting-associated protein 20

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024591.5NP_078867.2  charged multivesicular body protein 6

    See identical proteins and their annotated locations for NP_078867.2

    Status: VALIDATED

    Source sequence(s)
    AK223187, AK292105, BP196406
    Consensus CDS
    CCDS11774.1
    UniProtKB/Swiss-Prot
    A8K7U0, Q53FU4, Q96FZ7, Q9HAE8
    Related
    ENSP00000317468.5, ENST00000325167.9
    Conserved Domains (1) summary
    pfam03357
    Location:18177
    Snf7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    80991841..81000133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257668.1XP_005257725.1  charged multivesicular body protein 6 isoform X1

    UniProtKB/TrEMBL
    I3L4A1
    Related
    ENSP00000461098.1, ENST00000572778.5
    Conserved Domains (1) summary
    pfam03357
    Location:18177
    Snf7; Snf7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    81898759..81907012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317208.1XP_054173183.1  charged multivesicular body protein 6 isoform X1

    UniProtKB/TrEMBL
    I3L4A1