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CHMP6 charged multivesicular body protein 6 [ Homo sapiens (human) ]

Gene ID: 79643, updated on 12-Feb-2021

Summary

Official Symbol
CHMP6provided by HGNC
Official Full Name
charged multivesicular body protein 6provided by HGNC
Primary source
HGNC:HGNC:25675
See related
Ensembl:ENSG00000176108 MIM:610901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VPS20
Summary
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in biosynthesis of endosomes. [provided by RefSeq, Mar 2012]
Expression
Ubiquitous expression in kidney (RPKM 3.0), colon (RPKM 3.0) and 25 other tissues See more
Orthologs
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Genomic context

See CHMP6 in Genome Data Viewer
Location:
17q25.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (80991841..81000133)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (78965641..78973933)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene regulatory associated protein of MTOR complex 1 Neighboring gene uncharacterized LOC400627 Neighboring gene ribosomal protein L12 pseudogene 37 Neighboring gene uncharacterized LOC100129503 Neighboring gene BAIAP2 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag A fragment (amino acids 1-167) of CHMP6 is a potent dominant negative inhibitor of HIV-1 Gag release from cells PubMed
gag Budding of HIV-1 Gag with a PTAP point mutation is rescued by fusion to an ESCRT-III protein, CHMP6 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11749

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ESCRT III complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
endosomal transport TAS
Traceable Author Statement
more info
 
late endosome to vacuole transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
macroautophagy TAS
Traceable Author Statement
more info
PubMed 
midbody abscission IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
multivesicular body assembly TAS
Traceable Author Statement
more info
PubMed 
negative regulation of epidermal growth factor-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
NOT regulation of exosomal secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle budding from membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral budding via host ESCRT complex IDA
Inferred from Direct Assay
more info
PubMed 
viral life cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
ESCRT III complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ESCRT III complex IDA
Inferred from Direct Assay
more info
PubMed 
ESCRT III complex TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
charged multivesicular body protein 6
Names
chromatin-modifying protein 6
hVps20
vacuolar protein sorting-associated protein 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024591.5NP_078867.2  charged multivesicular body protein 6

    See identical proteins and their annotated locations for NP_078867.2

    Status: VALIDATED

    Source sequence(s)
    AK223187, AK292105, BP196406
    Consensus CDS
    CCDS11774.1
    UniProtKB/Swiss-Prot
    Q96FZ7
    Related
    ENSP00000317468.5, ENST00000325167.9
    Conserved Domains (1) summary
    pfam03357
    Location:18177
    Snf7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    80991841..81000133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257668.1XP_005257725.1  charged multivesicular body protein 6 isoform X1

    Related
    ENSP00000461098.1, ENST00000572778.5
    Conserved Domains (1) summary
    pfam03357
    Location:18177
    Snf7; Snf7
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