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ROGDI rogdi atypical leucine zipper [ Homo sapiens (human) ]

Gene ID: 79641, updated on 15-Jun-2019

Summary

Official Symbol
ROGDIprovided by HGNC
Official Full Name
rogdi atypical leucine zipperprovided by HGNC
Primary source
HGNC:HGNC:29478
See related
Ensembl:ENSG00000067836 MIM:614574
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KTZS
Summary
This gene encodes a protein of unknown function. Loss-of-function mutation in this gene cause Kohlschutter-Tonz syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Expression
Ubiquitous expression in brain (RPKM 26.0), bone marrow (RPKM 23.4) and 25 other tissues See more
Orthologs

Genomic context

See ROGDI in Genome Data Viewer
Location:
16p13.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (4796962..4802950, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4846963..4852951, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene chromosome 16 open reading frame 71 Neighboring gene zinc finger protein 500 Neighboring gene septin 12 Neighboring gene small integral membrane protein 22 Neighboring gene glyoxylate reductase 1 homolog Neighboring gene ubinuclein 1 Neighboring gene uncharacterized LOC105371064 Neighboring gene periplakin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22386

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
developmental process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
vacuolar acidification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
RAVE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein rogdi homolog
Names
leucine zipper domain protein
rogdi homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032174.1 RefSeqGene

    Range
    5001..10989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_455

mRNA and Protein(s)

  1. NM_024589.2NP_078865.1  protein rogdi homolog

    See identical proteins and their annotated locations for NP_078865.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AA740842, AC020663, BC012901
    Consensus CDS
    CCDS10523.1
    UniProtKB/Swiss-Prot
    Q9GZN7
    Related
    ENSP00000322832.5, ENST00000322048.11
    Conserved Domains (1) summary
    pfam10259
    Location:18276
    Rogdi_lz; Rogdi leucine zipper containing protein

RNA

  1. NR_046480.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA740842, AC020663, AK098348
    Related
    ENST00000587843.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    4796962..4802950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720948.4XP_006721011.1  protein rogdi homolog isoform X2

    Conserved Domains (1) summary
    pfam10259
    Location:1193
    Rogdi_lz; Rogdi leucine zipper containing protein
  2. XM_006720947.4XP_006721010.1  protein rogdi homolog isoform X1

    See identical proteins and their annotated locations for XP_006721010.1

    Conserved Domains (1) summary
    pfam10259
    Location:18283
    Rogdi_lz; Rogdi leucine zipper containing protein
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