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SCRN3 secernin 3 [ Homo sapiens (human) ]

Gene ID: 79634, updated on 9-Nov-2022

Summary

Official Symbol
SCRN3provided by HGNC
Official Full Name
secernin 3provided by HGNC
Primary source
HGNC:HGNC:30382
See related
Ensembl:ENSG00000144306 MIM:614967; AllianceGenome:HGNC:30382
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SES3
Summary
Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 6.9), thyroid (RPKM 5.5) and 25 other tissues See more
Orthologs
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Genomic context

See SCRN3 in Genome Data Viewer
Location:
2q31.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (174395730..174429575)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (174884418..174918222)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (175260458..175294303)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8106 Neighboring gene corepressor interacting with RBPJ, CIR1 Neighboring gene G protein-coupled receptor 155 Neighboring gene GPR155 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23142, MGC149597

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type exopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193528.2NP_001180457.1  secernin-3 isoform 2

    See identical proteins and their annotated locations for NP_001180457.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' coding region, which results in the use of an upstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AA227619, AK295357, BC031821, CK301138, DA760451
    Consensus CDS
    CCDS54420.1
    UniProtKB/Swiss-Prot
    Q0VDG4
    Related
    ENSP00000387142.3, ENST00000409673.7
    Conserved Domains (1) summary
    cl00467
    Location:48219
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  2. NM_001412202.1NP_001399131.1  secernin-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC018470
    UniProtKB/Swiss-Prot
    Q9H5R5
  3. NM_001412203.1NP_001399132.1  secernin-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC018470
    UniProtKB/Swiss-Prot
    Q9H5R5
  4. NM_001412204.1NP_001399133.1  secernin-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC018470
    UniProtKB/Swiss-Prot
    Q9H5R5
  5. NM_001412205.1NP_001399134.1  secernin-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC018470
    UniProtKB/Swiss-Prot
    Q9H5R5
  6. NM_001412206.1NP_001399135.1  secernin-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC018470
    UniProtKB/Swiss-Prot
    Q9H5R5
  7. NM_001412207.1NP_001399136.1  secernin-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC018470
    UniProtKB/Swiss-Prot
    Q9H5R5
  8. NM_001412208.1NP_001399137.1  secernin-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC018470
    UniProtKB/Swiss-Prot
    Q9H5R5
  9. NM_001412209.1NP_001399138.1  secernin-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC018470
  10. NM_001412210.1NP_001399139.1  secernin-3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC018470
  11. NM_001412212.1NP_001399141.1  secernin-3 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) uses the same exon combination as variant 1 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (5) has a frameshifted C-terminus compared to isoform 1.
    Source sequence(s)
    CP068276
    UniProtKB/TrEMBL
    Q0VDG5
  12. NM_024583.5NP_078859.2  secernin-3 isoform 1

    See identical proteins and their annotated locations for NP_078859.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses the same exon combination as variant 12 but represents the allele encoded by the GRCh38 reference genome. The encoded isoform (1) has a frameshifted C-terminus compared to isoform 5.
    Source sequence(s)
    AA227619, BC031821, BC119684, CK301138, DA760451
    Consensus CDS
    CCDS2258.1
    UniProtKB/Swiss-Prot
    Q0VDG4, Q9H5R5
    UniProtKB/TrEMBL
    Q0VDG5
    Related
    ENSP00000272732.6, ENST00000272732.11
    Conserved Domains (1) summary
    cl00467
    Location:5226
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    174395730..174429575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246854.6XP_005246911.1  secernin-3 isoform X2

    See identical proteins and their annotated locations for XP_005246911.1

    UniProtKB/Swiss-Prot
    Q0VDG4, Q9H5R5
    Conserved Domains (1) summary
    cl00467
    Location:5226
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  2. XM_047445829.1XP_047301785.1  secernin-3 isoform X3

  3. XM_047445828.1XP_047301784.1  secernin-3 isoform X2

  4. XM_017004910.3XP_016860399.1  secernin-3 isoform X2

    UniProtKB/Swiss-Prot
    Q0VDG4
    Conserved Domains (1) summary
    cl00467
    Location:5226
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  5. XM_005246855.4XP_005246912.1  secernin-3 isoform X2

    UniProtKB/Swiss-Prot
    Q0VDG4
    Conserved Domains (1) summary
    cl00467
    Location:5226
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  6. XM_005246853.4XP_005246910.1  secernin-3 isoform X1

    Conserved Domains (1) summary
    cl00467
    Location:25246
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  7. XM_005246857.4XP_005246914.1  secernin-3 isoform X2

    UniProtKB/Swiss-Prot
    Q0VDG4
    Conserved Domains (1) summary
    cl00467
    Location:5226
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  8. XM_011511839.4XP_011510141.1  secernin-3 isoform X3

    Conserved Domains (1) summary
    cl00467
    Location:2146
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    174884418..174918222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)