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TNFAIP8L2 TNF alpha induced protein 8 like 2 [ Homo sapiens (human) ]

Gene ID: 79626, updated on 5-Aug-2022

Summary

Official Symbol
TNFAIP8L2provided by HGNC
Official Full Name
TNF alpha induced protein 8 like 2provided by HGNC
Primary source
HGNC:HGNC:26277
See related
Ensembl:ENSG00000163154 MIM:612112; AllianceGenome:HGNC:26277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIPE2
Summary
Predicted to be involved in negative regulation of T cell activation and negative regulation of inflammatory response. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen (RPKM 30.0), lymph node (RPKM 26.2) and 14 other tissues See more
Orthologs
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Genomic context

See TNFAIP8L2 in Genome Data Viewer
Location:
1q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (151156649..151159749)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (150280351..150283451)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151129125..151132225)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904418 Neighboring gene semaphorin 6C Neighboring gene LysM domain containing 1 Neighboring gene TNFAIP8L2-SCNM1 readthrough Neighboring gene sodium channel modifier 1 Neighboring gene tropomodulin 4 Neighboring gene vacuolar protein sorting 72 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough TNFAIP8L2-SCNM1

Readthrough gene: TNFAIP8L2-SCNM1, Included gene: SCNM1

Homology

Clone Names

  • FLJ23467

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tumor necrosis factor alpha-induced protein 8-like protein 2
Names
TNF alpha-induced protein 8-like protein 2
TNFAIP8-like protein 2
inflammation factor 20
inflammation factor protein 20
tumor necrosis factor, alpha induced protein 8 like 2
tumor necrosis factor, alpha-induced protein 8-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024575.5NP_078851.2  tumor necrosis factor alpha-induced protein 8-like protein 2

    See identical proteins and their annotated locations for NP_078851.2

    Status: VALIDATED

    Source sequence(s)
    BC063014, BI833715
    Consensus CDS
    CCDS985.1
    UniProtKB/Swiss-Prot
    Q6P589, Q9H5G2
    Related
    ENSP00000357906.3, ENST00000368910.4
    Conserved Domains (1) summary
    pfam05527
    Location:5181
    DUF758; Domain of unknown function (DUF758)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    151156649..151159749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    150280351..150283451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)