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ARMT1 acidic residue methyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 79624, updated on 17-Sep-2024

Summary

Official Symbol
ARMT1provided by HGNC
Official Full Name
acidic residue methyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:17872
See related
Ensembl:ENSG00000146476 MIM:616332; AllianceGenome:HGNC:17872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C6orf211
Summary
Enables S-adenosylmethionine-dependent methyltransferase activity; enzyme binding activity; and protein carboxyl O-methyltransferase activity. Involved in methylation and regulation of response to DNA damage stimulus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 18.3), kidney (RPKM 17.3) and 24 other tissues See more
Orthologs
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Genomic context

See ARMT1 in Genome Data Viewer
Location:
6q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (151452466..151470101)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (152653108..152670749)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (151773601..151791236)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901433 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 15 Neighboring gene required for meiotic nuclear division 1 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17688 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:151776537-151777294 Neighboring gene uncharacterized LOC124901434 Neighboring gene uncharacterized LOC124901436 Neighboring gene coiled-coil domain containing 170

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ12910, DKFZp566I174

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables fructose 6-phosphate aldolase activity IEA
Inferred from Electronic Annotation
more info
 
enables fructose-1-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein carboxyl O-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-glutamate O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
damage-control phosphatase ARMT1
Names
UPF0364 protein C6orf211
protein-glutamate O-methyltransferase
sugar phosphate phosphatase ARMT1
NP_001273491.1
NP_078849.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286562.2NP_001273491.1  damage-control phosphatase ARMT1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' region, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK022972, AK298490, BC011348, DB443862
    Consensus CDS
    CCDS69224.1
    UniProtKB/TrEMBL
    B4DPT6, F5GZY1
    Related
    ENSP00000444121.1, ENST00000545879.5
    Conserved Domains (1) summary
    pfam01937
    Location:1300
    DUF89; Protein of unknown function DUF89
  2. NM_024573.3NP_078849.1  damage-control phosphatase ARMT1 isoform a

    See identical proteins and their annotated locations for NP_078849.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK022972, BC011348
    Consensus CDS
    CCDS5233.1
    UniProtKB/Swiss-Prot
    Q96FC6, Q9H993, Q9UFY5
    Related
    ENSP00000356263.3, ENST00000367294.4
    Conserved Domains (1) summary
    pfam01937
    Location:20419
    DUF89; Protein of unknown function DUF89

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    151452466..151470101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    152653108..152670749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)