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SNRNP25 small nuclear ribonucleoprotein U11/U12 subunit 25 [ Homo sapiens (human) ]

Gene ID: 79622, updated on 8-Jul-2021

Summary

Official Symbol
SNRNP25provided by HGNC
Official Full Name
small nuclear ribonucleoprotein U11/U12 subunit 25provided by HGNC
Primary source
HGNC:HGNC:14161
See related
Ensembl:ENSG00000161981
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C16orf33
Summary
Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 25K protein that is a component of the U12-type spliceosome. [provided by RefSeq, Apr 2010]
Expression
Ubiquitous expression in brain (RPKM 19.4), heart (RPKM 18.6) and 25 other tissues See more
Orthologs
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Genomic context

See SNRNP25 in Genome Data Viewer
Location:
16p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (53828..57669)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (103828..107669)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene interleukin 9 receptor pseudogene 3 Neighboring gene RNA polymerase III subunit K Neighboring gene rhomboid 5 homolog 1 Neighboring gene N-methylpurine DNA glycosylase Neighboring gene NPR3 like, GATOR1 complex subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22940

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IC
Inferred by Curator
more info
PubMed 
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of U12-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U12-type spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
U11/U12 small nuclear ribonucleoprotein 25 kDa protein
Names
U11/U12 snRNP 25 kDa protein
U11/U12 snRNP 25K
minus-99 protein
small nuclear ribonucleoprotein 25kDa (U11/U12)
small nuclear ribonucleoprotein, U11/U12 25kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017004.1 RefSeqGene

    Range
    5000..8841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024571.4NP_078847.2  U11/U12 small nuclear ribonucleoprotein 25 kDa protein

    Status: REVIEWED

    Source sequence(s)
    Z69719
    Consensus CDS
    CCDS10396.1
    Related
    ENSP00000293861.3, ENST00000293861.8
    Conserved Domains (1) summary
    cd17058
    Location:31119
    Ubl_SNRNP25; ubiquitin-like (Ubl) domain found in small nuclear ribonucleoprotein U11/U12 subunit 25 (SNRNP25) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    53828..57669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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