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NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit [ Homo sapiens (human) ]

Gene ID: 79612, updated on 17-Jun-2019

Summary

Official Symbol
NAA16provided by HGNC
Official Full Name
N(alpha)-acetyltransferase 16, NatA auxiliary subunitprovided by HGNC
Primary source
HGNC:HGNC:26164
See related
Ensembl:ENSG00000172766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NARG1L
Expression
Ubiquitous expression in bone marrow (RPKM 4.0), testis (RPKM 2.5) and 25 other tissues See more
Orthologs

Genomic context

See NAA16 in Genome Data Viewer
Location:
13q14.11
Exon count:
23
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (41311239..41377031)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (41885341..41951166)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene mitochondrial translation release factor 1 Neighboring gene uncharacterized LOC105370173 Neighboring gene Rac family small GTPase 1 pseudogene 3 Neighboring gene RNA, U6 small nuclear 57, pseudogene Neighboring gene Sharpr-MPRA regulatory region 5068 Neighboring gene tubulin beta pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC40612, DKFZp686O08147

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to peptide alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to peptide alpha-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
N-terminal peptidyl-methionine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-terminal protein amino acid acetylation IDA
Inferred from Direct Assay
more info
PubMed 
N-terminal protein amino acid acetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
NatA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NatA complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
N-alpha-acetyltransferase 16, NatA auxiliary subunit
Names
NARG1-like protein
NMDA receptor-regulated 1-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110798.2NP_001104268.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform 3

    See identical proteins and their annotated locations for NP_001104268.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several coding exons and differs in the 3' UTR, compared to variant 1, resulting in a shorter protein (isoform 3) with a unique C-terminus, compared to isoform 1.
    Source sequence(s)
    AL590665, BC064592, BE501152, DB078940
    Consensus CDS
    CCDS45044.1
    UniProtKB/Swiss-Prot
    Q6N069
    Related
    ENSP00000386103.3, ENST00000403412.7
    Conserved Domains (3) summary
    sd00006
    Location:82108
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:87113
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:82145
    TPR_11; TPR repeat
  2. NM_018527.4NP_060997.2  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform 2

    See identical proteins and their annotated locations for NP_060997.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal coding exon and several 3' exons but has an alternate 3' segment, compared to variant 1. The resulting isoform (2) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL590665, BC032318, DB078940
    UniProtKB/Swiss-Prot
    Q6N069
    Conserved Domains (3) summary
    sd00006
    Location:82108
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:87113
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:82145
    TPR_11; TPR repeat
  3. NM_024561.5NP_078837.3  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform 1

    See identical proteins and their annotated locations for NP_078837.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK097224, AL590665, AL731858, AL833341, DB078940
    Consensus CDS
    CCDS9379.1
    UniProtKB/Swiss-Prot
    Q6N069
    UniProtKB/TrEMBL
    A4FU51
    Related
    ENSP00000368716.3, ENST00000379406.8
    Conserved Domains (4) summary
    sd00006
    Location:82108
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:87113
    TPR_1; Tetratricopeptide repeat
    pfam12569
    Location:187698
    NARP1; NMDA receptor-regulated protein 1
    pfam13414
    Location:82145
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    41311239..41377031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719866.3XP_006719929.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X1

    Conserved Domains (4) summary
    sd00006
    Location:82108
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:87113
    TPR_1; Tetratricopeptide repeat
    pfam12569
    Location:187638
    NARP1; NMDA receptor-regulated protein 1
    pfam13414
    Location:82145
    TPR_11; TPR repeat
  2. XM_011535227.3XP_011533529.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X2

    Conserved Domains (4) summary
    sd00006
    Location:82108
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:87113
    TPR_1; Tetratricopeptide repeat
    pfam12569
    Location:187698
    NARP1; NMDA receptor-regulated protein 1
    pfam13414
    Location:82145
    TPR_11; TPR repeat
  3. XM_011535228.2XP_011533530.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X3

    See identical proteins and their annotated locations for XP_011533530.1

    UniProtKB/Swiss-Prot
    Q6N069
    Related
    ENSP00000432364.1, ENST00000464857.5
    Conserved Domains (3) summary
    sd00006
    Location:82108
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:87113
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:82145
    TPR_11; TPR repeat
  4. XM_017020746.2XP_016876235.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X6

  5. XM_017020745.2XP_016876234.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X5

  6. XM_017020744.1XP_016876233.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X4

    Conserved Domains (1) summary
    pfam12569
    Location:1286
    NARP1; NMDA receptor-regulated protein 1
  7. XM_005266523.2XP_005266580.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X4

    Conserved Domains (1) summary
    pfam12569
    Location:1286
    NARP1; NMDA receptor-regulated protein 1

RNA

  1. XR_001749669.2 RNA Sequence

  2. XR_001749671.2 RNA Sequence

  3. XR_002957473.1 RNA Sequence

  4. XR_001749675.2 RNA Sequence

  5. XR_001749673.2 RNA Sequence

  6. XR_001749670.2 RNA Sequence

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