ADIPOR2 adiponectin receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADIPOR2provided by HGNC
Official Full Name: adiponectin receptor 2provided by HGNC
Primary source: HGNC:HGNC:24041
See related: Ensembl:ENSG00000006831 MIM:607946; AllianceGenome:HGNC:24041
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PAQR2; ACDCR2
Summary: The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
Expression: Ubiquitous expression in fat (RPKM 49.9), adrenal (RPKM 34.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12p13.33

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (1691070..1788674)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (1687685..1784807)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (1800236..1897840)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings.
Title: Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings.
AdipoR2 inhibits human glioblastoma cell growth through the AMPK/mTOR pathway.
Title: AdipoR2 inhibits human glioblastoma cell growth through the AMPK/mTOR pathway.
Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty acids.
Title: Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty acids.
The expression and relationship of AdipoR1/R2 in gastric intestinal metaplasia.
Title: The expression and relationship of AdipoR1/R2 in gastric intestinal metaplasia.
Adiponectin is associated with cardio-metabolic traits in Mexican children.
Title: Adiponectin is associated with cardio-metabolic traits in Mexican children.
Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins.
Title: Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins.
The primary cellular function of AdipoR2 is to maintain membrane fluidity in most human cell types and that adiponectin is not required for this function.
Title: AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of adiponectin.
Human diabetic kidneys show decreased intraglomerular AdipoR1/AdipoR2 expression.
Title: The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes.
AdipoR2 single nucleotide polymorphism is associated with increases glomerular filtration rate.
Title: Adiponectin Receptor gene Polymorphisms are Associated with Kidney Function in Elderly Japanese Populations.
There were no significant associations involving ADIPOR2 with diabetes and hypertriglyceridemia in an admixed Latin American population.
Title: Variations in ADIPOR1 But Not ADIPOR2 are Associated With Hypertriglyceridemia and Diabetes in an Admixed Latin American Population.

Submit: New GeneRIF Correction See all GeneRIFs (128)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-82266 (e-PCR)
- UniSTS:104213

Adipor2 (e-PCR), detects polymorphism
- UniSTS:471067

G20673 (e-PCR)
- UniSTS:77345

A006B15 (e-PCR)
- UniSTS:77346

G42618 (e-PCR)
- UniSTS:94518

SHGC-82005 (e-PCR)
- UniSTS:102978

D12S1656 (e-PCR), detects polymorphism
- UniSTS:9812

SHGC-84708 (e-PCR)
- UniSTS:104104

RH66215 (e-PCR)
- UniSTS:51116

SHGC-84820 (e-PCR)
- UniSTS:104179

Homology

Homologs of the ADIPOR2 gene: The ADIPOR2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, A.thaliana, and rice.
Orthologs from Annotation Pipeline: 350 organisms have orthologs with human gene ADIPOR2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables adipokinetic hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables adiponectin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in adiponectin-activated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in adiponectin-activated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid oxidation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in hormone-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in vascular wound healing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: adiponectin receptor protein 2

Names: progestin and adipoQ receptor family member 2; progestin and adipoQ receptor family member II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001375363.1 → NP_001362292.1 adiponectin receptor protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC005183, AC005343

Conserved Domains (1) summary

pfam03006
Location:140 → 396

HlyIII; Haemolysin-III related
NM_001375364.1 → NP_001362293.1 adiponectin receptor protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC005183, AC005343

Consensus CDS

CCDS8511.1

UniProtKB/Swiss-Prot

Q9H737

Conserved Domains (1) summary

pfam03006
Location:140 → 363

HlyIII; Haemolysin-III related
NM_001375365.1 → NP_001362294.1 adiponectin receptor protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC005183, AC005343

Consensus CDS

CCDS8511.1

UniProtKB/Swiss-Prot

Q9H737

Conserved Domains (1) summary

pfam03006
Location:140 → 363

HlyIII; Haemolysin-III related
NM_024551.3 → NP_078827.2 adiponectin receptor protein 2 isoform 2

See identical proteins and their annotated locations for NP_078827.2

Status: VALIDATED

Source sequence(s)

AC005183, AC005343

Consensus CDS

CCDS8511.1

UniProtKB/Swiss-Prot

Q86V24, Q9H737

Related

ENSP00000349616.4, ENST00000357103.5

Conserved Domains (1) summary

pfam03006
Location:140 → 363

HlyIII; Haemolysin-III related