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ARMH3 armadillo like helical domain containing 3 [ Homo sapiens (human) ]

Gene ID: 79591, updated on 3-Mar-2026
Official Symbol
ARMH3provided by HGNC
Official Full Name
armadillo like helical domain containing 3provided by HGNC
Primary source
HGNC:HGNC:25788
See related
Ensembl:ENSG00000120029 MIM:620867; AllianceGenome:HGNC:25788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DGARM; C10orf76
Summary
Involved in regulation of Golgi organization. Located in Golgi membrane and cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in heart (RPKM 8.1), esophagus (RPKM 4.9) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ARMH3 in Genome Data Viewer
Location:
10q24.32
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (101845599..102056173, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (102729087..102941253, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103605356..103815930, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103577734-103578309 Neighboring gene Sharpr-MPRA regulatory region 4495 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103587343-103588542 Neighboring gene KCNIP2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2730 Neighboring gene O-GlcNAcase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2731 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103590597-103591113 Neighboring gene Sharpr-MPRA regulatory region 3638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103596213-103596713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2733 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103603069-103603574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2734 Neighboring gene uncharacterized LOC101927445 Neighboring gene potassium voltage-gated channel interacting protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3918 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:103662223-103662886 Neighboring gene uncharacterized LOC124902492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2735 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103698366-103699565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103795088-103795895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2737 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2738 Neighboring gene HPS6 biogenesis of lysosomal organelles complex 2 subunit 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103867277-103867778 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103870016-103871215 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2739 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103876901-103877603 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103877604-103878305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2745 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103880011-103880762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:103880763-103881514 Neighboring gene LIM domain binding 1 Neighboring gene PPARG related coactivator 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. DGARM/C10orf76/ARMH3 for Ceramide Transfer Zone at the Endoplasmic Reticulum-Distal Golgi Contacts. Mizuike A, et al. Contact (Thousand Oaks), 2024 Jan-Dec. PMID 38515862, Free PMC Article
  2. Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication. McPhail JA, et al. EMBO Rep, 2020 Feb 5. PMID 31829496, Free PMC Article
  3. The C10orf76-PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi. Mizuike A, et al. J Cell Biol, 2023 Jul 3. PMID 37195633, Free PMC Article
  4. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. Greninger AL, et al. mBio, 2013 Apr 9. PMID 23572552, Free PMC Article
  5. Genetics of coronary artery calcification among African Americans, a meta-analysis. Wojczynski MK, et al. BMC Med Genet, 2013 Jul 19. PMID 23870195, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The C10orf76-PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi.
    Title: The C10orf76-PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog
Genetics of coronary artery calcification among African Americans, a meta-analysis.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ13114, MGC125927

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
armadillo-like helical domain-containing protein 3
Names
UPF0668 protein C10orf76
distal Golgi armadillo repeat protein

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024541.3 → NP_078817.2  armadillo-like helical domain-containing protein 3

    See identical proteins and their annotated locations for NP_078817.2

    Status: VALIDATED

    Source sequence(s)
    AK023176, AK097972, AW936405, DA020448, DA311439, DR002231, DT932690
    Consensus CDS
    CCDS41563.1
    UniProtKB/Swiss-Prot
    Q2TB87, Q5T2E6, Q9H8Z9
    Related
    ENSP00000359050.4, ENST00000370033.9
    Conserved Domains (1) summary
    pfam08427
    Location:441 → 669
    DUF1741; Domain of unknown function (DUF1741)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    101845599..102056173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425735.1 → XP_047281691.1  armadillo-like helical domain-containing protein 3 isoform X9

  2. XM_011540157.3 → XP_011538459.1  armadillo-like helical domain-containing protein 3 isoform X5

    Conserved Domains (1) summary
    pfam08427
    Location:390 → 618
    DUF1741; Domain of unknown function (DUF1741)

  3. XM_011540154.3 → XP_011538456.1  armadillo-like helical domain-containing protein 3 isoform X7

    See identical proteins and their annotated locations for XP_011538456.1

    Related
    ENSP00000621158.1, ENST00000951099.1
    Conserved Domains (1) summary
    pfam08427
    Location:385 → 613
    DUF1741; Domain of unknown function (DUF1741)

  4. XM_047425737.1 → XP_047281693.1  armadillo-like helical domain-containing protein 3 isoform X11

    Related
    ENSP00000591967.1, ENST00000921908.1

  5. XM_011540153.3 → XP_011538455.1  armadillo-like helical domain-containing protein 3 isoform X4

    See identical proteins and their annotated locations for XP_011538455.1

    Related
    ENSP00000566917.1, ENST00000896858.1
    Conserved Domains (1) summary
    pfam08427
    Location:407 → 635
    DUF1741; Domain of unknown function (DUF1741)

  6. XM_047425736.1 → XP_047281692.1  armadillo-like helical domain-containing protein 3 isoform X10

  7. XM_011540152.3 → XP_011538454.1  armadillo-like helical domain-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_011538454.1

    Conserved Domains (1) summary
    pfam08427
    Location:419 → 647
    DUF1741; Domain of unknown function (DUF1741)

  8. XM_006717969.1 → XP_006718032.1  armadillo-like helical domain-containing protein 3 isoform X8

    Related
    ENSP00000566913.1, ENST00000896854.1
    Conserved Domains (1) summary
    pfam08427
    Location:441 → 599
    DUF1741; Domain of unknown function (DUF1741)

  9. XM_047425734.1 → XP_047281690.1  armadillo-like helical domain-containing protein 3 isoform X8

  10. XM_011540151.4 → XP_011538453.1  armadillo-like helical domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011538453.1

    UniProtKB/Swiss-Prot
    Q2TB87, Q5T2E6, Q9H8Z9
    Related
    ENSP00000566922.1, ENST00000896863.1
    Conserved Domains (1) summary
    pfam08427
    Location:441 → 669
    DUF1741; Domain of unknown function (DUF1741)

  11. XM_011540156.3 → XP_011538458.1  armadillo-like helical domain-containing protein 3 isoform X14

    Conserved Domains (1) summary
    pfam08427
    Location:267 → 495
    DUF1741; Domain of unknown function (DUF1741)

  12. XM_017016635.2 → XP_016872124.1  armadillo-like helical domain-containing protein 3 isoform X3

    Conserved Domains (1) summary
    pfam08427
    Location:441 → 620
    DUF1741; Domain of unknown function (DUF1741)

  13. XM_047425733.1 → XP_047281689.1  armadillo-like helical domain-containing protein 3 isoform X6

  14. XM_017016636.3 → XP_016872125.1  armadillo-like helical domain-containing protein 3 isoform X6

    Conserved Domains (1) summary
    pfam08427
    Location:441 → 620
    DUF1741; Domain of unknown function (DUF1741)

  15. XM_047425740.1 → XP_047281696.1  armadillo-like helical domain-containing protein 3 isoform X13

  16. XM_047425738.1 → XP_047281694.1  armadillo-like helical domain-containing protein 3 isoform X12

RNA

  1. XR_001747199.2 RNA Sequence

  2. XR_007061987.1 RNA Sequence

  3. XR_007061988.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    102729087..102941253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366718.1 → XP_054222693.1  armadillo-like helical domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q2TB87, Q5T2E6, Q9H8Z9

  2. XM_054366726.1 → XP_054222701.1  armadillo-like helical domain-containing protein 3 isoform X8

  3. XM_054366727.1 → XP_054222702.1  armadillo-like helical domain-containing protein 3 isoform X9

  4. XM_054366722.1 → XP_054222697.1  armadillo-like helical domain-containing protein 3 isoform X5

  5. XM_054366724.1 → XP_054222699.1  armadillo-like helical domain-containing protein 3 isoform X7

  6. XM_054366729.1 → XP_054222704.1  armadillo-like helical domain-containing protein 3 isoform X11

  7. XM_054366721.1 → XP_054222696.1  armadillo-like helical domain-containing protein 3 isoform X4

  8. XM_054366728.1 → XP_054222703.1  armadillo-like helical domain-containing protein 3 isoform X10

  9. XM_054366719.1 → XP_054222694.1  armadillo-like helical domain-containing protein 3 isoform X2

  10. XM_054366725.1 → XP_054222700.1  armadillo-like helical domain-containing protein 3 isoform X8

  11. XM_054366732.1 → XP_054222707.1  armadillo-like helical domain-containing protein 3 isoform X14

  12. XM_054366720.1 → XP_054222695.1  armadillo-like helical domain-containing protein 3 isoform X3

  13. XM_054366723.1 → XP_054222698.1  armadillo-like helical domain-containing protein 3 isoform X6

  14. XM_054366731.1 → XP_054222706.1  armadillo-like helical domain-containing protein 3 isoform X13

  15. XM_054366730.1 → XP_054222705.1  armadillo-like helical domain-containing protein 3 isoform X12

RNA

  1. XR_008488263.1 RNA Sequence

  2. XR_008488264.1 RNA Sequence

  3. XR_008488265.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T2E6.1 GenPept UniProtKB/Swiss-Prot:Q5T2E6

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