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RNF128 ring finger protein 128 [ Homo sapiens (human) ]

Gene ID: 79589, updated on 24-Nov-2020

Summary

Official Symbol
RNF128provided by HGNC
Official Full Name
ring finger protein 128provided by HGNC
Primary source
HGNC:HGNC:21153
See related
Ensembl:ENSG00000133135 MIM:300439
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRAIL
Summary
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Broad expression in small intestine (RPKM 27.8), liver (RPKM 27.8) and 15 other tissues See more
Orthologs

Genomic context

See RNF128 in Genome Data Viewer
Location:
Xq22.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (106693838..106797016)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (105937068..106040246)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene serpin family A member 7 pseudogene 1 Neighboring gene RPA1 related single stranded DNA binding protein, X-linked Neighboring gene microRNA 548an Neighboring gene TBC1 domain family member 8B Neighboring gene ripply transcriptional repressor 1 Neighboring gene claudin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23516

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
negative regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein catabolic process in the vacuole IC
Inferred by Curator
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein localization to lysosome IC
Inferred by Curator
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF128
Names
RING-type E3 ubiquitin transferase RNF128
gene related to anergy in lymphocytes protein
ring finger protein 128, E3 ubiquitin protein ligase
NP_078815.3
NP_919445.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012576.1 RefSeqGene

    Range
    5001..108179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024539.3NP_078815.3  E3 ubiquitin-protein ligase RNF128 isoform 2 precursor

    See identical proteins and their annotated locations for NP_078815.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' end exon compared to variant 1. The resulting isoform (2) has a distinct and shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK027169, BC012931, BC036901
    Consensus CDS
    CCDS14520.1
    UniProtKB/Swiss-Prot
    Q8TEB7
    Related
    ENSP00000316127.3, ENST00000324342.7
    Conserved Domains (2) summary
    cd02122
    Location:34167
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    pfam13639
    Location:249292
    zf-RING_2; Ring finger domain
  2. NM_194463.2NP_919445.1  E3 ubiquitin-protein ligase RNF128 isoform 1 precursor

    See identical proteins and their annotated locations for NP_919445.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK074264, BC012931, BI600046
    Consensus CDS
    CCDS14521.1
    UniProtKB/Swiss-Prot
    Q8TEB7
    Related
    ENSP00000255499.2, ENST00000255499.3
    Conserved Domains (2) summary
    cd02122
    Location:48193
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    cd16802
    Location:275323
    RING-H2_RNF128_like; RING finger, H2 subclass, found in RING finger protein 128 (RNF128) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    106693838..106797016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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