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CORO7 coronin 7 [ Homo sapiens (human) ]

Gene ID: 79585, updated on 13-Feb-2019

Summary

Official Symbol
CORO7provided by HGNC
Official Full Name
coronin 7provided by HGNC
Primary source
HGNC:HGNC:26161
See related
Ensembl:ENSG00000262246 MIM:611668
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRN7; POD1; 0610011B16Rik
Summary
This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016]
Expression
Broad expression in bone marrow (RPKM 25.2), spleen (RPKM 18.8) and 24 other tissues See more
Orthologs

Genomic context

See CORO7 in Genome Data Viewer
Location:
16p13.3
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (4354542..4416961, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4404543..4466962, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene GLIS2 antisense RNA 1 Neighboring gene GLIS family zinc finger 2 Neighboring gene CORO7-PAM16 readthrough Neighboring gene presequence translocase associated motor 16 Neighboring gene vasorin Neighboring gene DnaJ heat shock protein family (Hsp40) member A3 Neighboring gene NmrA like redox sensor 1 Neighboring gene heme oxygenase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough CORO7-PAM16

Readthrough gene: CORO7-PAM16, Included gene: PAM16

Homology

Clone Names

  • FLJ22021, FLJ44188

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi to endosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane HDA PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
coronin-7
Names
70 kDa WD repeat tumor rejection antigen homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052966.1 RefSeqGene

    Range
    5001..67420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201472.1NP_001188401.1  coronin-7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC012676, AK294045, BM671637, DR155527
    Consensus CDS
    CCDS58417.1
    UniProtKB/Swiss-Prot
    P57737
    Related
    ENSP00000440460.2, ENST00000537233.6
    Conserved Domains (4) summary
    pfam08953
    Location:560
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:790834
    WD40_4; Type of WD40 repeat
    sd00039
    Location:486522
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:528686
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001201473.1NP_001188402.1  coronin-7 isoform 3

    See identical proteins and their annotated locations for NP_001188402.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two exons that result in a missing in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK296807, BM671637, DR155527
    Consensus CDS
    CCDS55982.1
    UniProtKB/Swiss-Prot
    P57737
    Related
    ENSP00000461702.1, ENST00000574025.5
    Conserved Domains (4) summary
    pfam08953
    Location:560
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:723767
    WD40_4; Type of WD40 repeat
    sd00039
    Location:419455
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:461619
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001351729.1NP_001338658.1  coronin-7 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AK094596, BM671637, DA234977, DA944874
    Conserved Domains (2) summary
    sd00039
    Location:284320
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:251660
    WD40_4; Type of WD40 repeat
  4. NM_024535.5NP_078811.3  coronin-7 isoform 1

    See identical proteins and their annotated locations for NP_078811.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC117291, BM671637, DR155527
    Consensus CDS
    CCDS10513.1
    UniProtKB/Swiss-Prot
    P57737
    Related
    ENSP00000251166.4, ENST00000251166.8
    Conserved Domains (2) summary
    sd00039
    Location:81124
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:471880
    WD40_4; Type of WD40 repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    4354542..4416961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187608.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    56867..119284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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