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TTC13 tetratricopeptide repeat domain 13 [ Homo sapiens (human) ]

Gene ID: 79573, updated on 1-Jun-2020

Summary

Official Symbol
TTC13provided by HGNC
Official Full Name
tetratricopeptide repeat domain 13provided by HGNC
Primary source
HGNC:HGNC:26204
See related
Ensembl:ENSG00000143643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in lymph node (RPKM 8.0), spleen (RPKM 5.6) and 25 other tissues See more
Orthologs

Genomic context

See TTC13 in Genome Data Viewer
Location:
1q42.2
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (230906243..230978872, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (231041987..231114618, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927604 Neighboring gene uncharacterized LOC105373167 Neighboring gene RNA, 7SL, cytoplasmic 837, pseudogene Neighboring gene ARV1 homolog, fatty acid homeostasis modulator Neighboring gene microRNA 1182 Neighboring gene family with sequence similarity 89 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22584

General protein information

Preferred Names
tetratricopeptide repeat protein 13
Names
TPR repeat protein 13
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122835.3NP_001116307.2  tetratricopeptide repeat protein 13 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the middle portion of the coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AK075386, AK075561, BC047662, DA741498, EL946523
    Consensus CDS
    CCDS44332.2
    UniProtKB/Swiss-Prot
    Q8NBP0
    Related
    ENSP00000355622.4, ENST00000366662.8
    Conserved Domains (4) summary
    sd00006
    Location:196224
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:264297
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:229294
    TPR_11; TPR repeat
    pfam13424
    Location:149228
    TPR_12; Tetratricopeptide repeat
  2. NM_001376507.1NP_001363436.1  tetratricopeptide repeat protein 13 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL844165, FO393421
  3. NM_001376508.1NP_001363437.1  tetratricopeptide repeat protein 13 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL844165, FO393421
  4. NM_001376509.1NP_001363438.1  tetratricopeptide repeat protein 13 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL844165, FO393421
  5. NM_001376510.1NP_001363439.1  tetratricopeptide repeat protein 13 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL844165, FO393421
  6. NM_001376511.1NP_001363440.1  tetratricopeptide repeat protein 13 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL844165, FO393421
  7. NM_001376512.1NP_001363441.1  tetratricopeptide repeat protein 13 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL844165, FO393421
  8. NM_001376513.1NP_001363442.1  tetratricopeptide repeat protein 13 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL844165, FO393421
  9. NM_001376514.1NP_001363443.1  tetratricopeptide repeat protein 13 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL844165, FO393421
  10. NM_024525.5NP_078801.3  tetratricopeptide repeat protein 13 isoform a

    See identical proteins and their annotated locations for NP_078801.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK074365, AK075386, AK075561, DA468037, DA741498, EL946523
    Consensus CDS
    CCDS1588.1
    UniProtKB/Swiss-Prot
    Q8NBP0
    Related
    ENSP00000355621.4, ENST00000366661.9
    Conserved Domains (2) summary
    sd00006
    Location:249277
    TPR; TPR repeat [structural motif]
    cl26002
    Location:119418
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    230906243..230978872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002325.1XP_016857814.1  tetratricopeptide repeat protein 13 isoform X13

    Conserved Domains (2) summary
    sd00006
    Location:2656
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:358
    TPR_11; TPR repeat
  2. XM_005273264.2XP_005273321.1  tetratricopeptide repeat protein 13 isoform X5

    Conserved Domains (3) summary
    sd00006
    Location:241269
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:241274
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:242306
    TPR_11; TPR repeat
  3. XM_006711815.3XP_006711878.1  tetratricopeptide repeat protein 13 isoform X12

    See identical proteins and their annotated locations for XP_006711878.1

    Conserved Domains (2) summary
    sd00006
    Location:2656
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:358
    TPR_11; TPR repeat
  4. XM_011544276.2XP_011542578.1  tetratricopeptide repeat protein 13 isoform X11

    Conserved Domains (3) summary
    sd00006
    Location:1949
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:2053
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:2185
    TPR_11; TPR repeat
  5. XM_006711814.2XP_006711877.1  tetratricopeptide repeat protein 13 isoform X7

    Conserved Domains (4) summary
    sd00006
    Location:188216
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:188221
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:189253
    TPR_11; TPR repeat
    pfam13424
    Location:149215
    TPR_12; Tetratricopeptide repeat

RNA

  1. XR_001737405.1 RNA Sequence

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