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ATP13A3 ATPase 13A3 [ Homo sapiens (human) ]

Gene ID: 79572, updated on 11-Sep-2019

Summary

Official Symbol
ATP13A3provided by HGNC
Official Full Name
ATPase 13A3provided by HGNC
Primary source
HGNC:HGNC:24113
See related
Ensembl:ENSG00000133657 MIM:610232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AFURS1
Summary
ATP13A3 is a member of the P-type ATPase family of proteins that transport a variety of cations across membranes. Other P-type ATPases include ATP7B (MIM 606882) and ATP7A (MIM 300011).[supplied by OMIM, Aug 2008]
Expression
Ubiquitous expression in thyroid (RPKM 24.7), appendix (RPKM 18.3) and 25 other tissues See more
Orthologs

Genomic context

See ATP13A3 in Genome Data Viewer
Location:
3q29
Exon count:
36
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (194402674..194487006, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (194123403..194188968, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 15 Neighboring gene glycoprotein V platelet Neighboring gene long intergenic non-protein coding RNA 884 Neighboring gene RNA, U6 small nuclear 1101, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ATP13A3 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90613, DKFZp686K16189

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cation transport IEA
Inferred from Electronic Annotation
more info
 
cellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
probable cation-transporting ATPase 13A3
Names
ATPase family homolog up-regulated in senescence cells 1
ATPase type 13A3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367549.1NP_001354478.1  probable cation-transporting ATPase 13A3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC108676, AC125362
  2. NM_024524.3NP_078800.3  probable cation-transporting ATPase 13A3 isoform 1

    See identical proteins and their annotated locations for NP_078800.3

    Status: VALIDATED

    Source sequence(s)
    AK075094, AK225064, BC106085, BP313821, DA852339, DR005713, DR423199, DV080200
    Consensus CDS
    CCDS43187.1
    UniProtKB/Swiss-Prot
    Q9H7F0
    Related
    ENSP00000256031.4, ENST00000256031.8
    Conserved Domains (6) summary
    TIGR01657
    Location:141149
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:236483
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:178226
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12409
    Location:13145
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:622662
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:821898
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    194402674..194487006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513123.2XP_011511425.1  probable cation-transporting ATPase 13A3 isoform X3

    See identical proteins and their annotated locations for XP_011511425.1

    UniProtKB/Swiss-Prot
    Q9H7F0
    Related
    ENSP00000494471.1, ENST00000645538.1
    Conserved Domains (6) summary
    TIGR01657
    Location:141149
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:236483
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:178226
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12409
    Location:13145
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:622662
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:821898
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  2. XM_011513122.1XP_011511424.1  probable cation-transporting ATPase 13A3 isoform X2

    Related
    ENSP00000493923.1, ENST00000642744.1
    Conserved Domains (6) summary
    TIGR01657
    Location:141122
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:209456
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:164199
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12409
    Location:13145
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:595635
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:794871
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  3. XM_005269357.3XP_005269414.1  probable cation-transporting ATPase 13A3 isoform X1

    See identical proteins and their annotated locations for XP_005269414.1

    Conserved Domains (6) summary
    TIGR01657
    Location:141149
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:236483
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:178226
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12409
    Location:13145
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:622662
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:821898
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  4. XM_011513121.1XP_011511423.1  probable cation-transporting ATPase 13A3 isoform X1

    See identical proteins and their annotated locations for XP_011511423.1

    Related
    ENSP00000494937.1, ENST00000645319.1
    Conserved Domains (6) summary
    TIGR01657
    Location:141149
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:236483
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:178226
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12409
    Location:13145
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:622662
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:821898
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  5. XM_011513124.3XP_011511426.1  probable cation-transporting ATPase 13A3 isoform X4

    Conserved Domains (6) summary
    TIGR01657
    Location:141149
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:236483
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:178226
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12409
    Location:13145
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:622662
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:821898
    HAD_like; Haloacid Dehalogenase-like Hydrolases
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