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ATP13A3 ATPase 13A3 [ Homo sapiens (human) ]

Gene ID: 79572, updated on 22-Sep-2022

Summary

Official Symbol
ATP13A3provided by HGNC
Official Full Name
ATPase 13A3provided by HGNC
Primary source
HGNC:HGNC:24113
See related
Ensembl:ENSG00000133657 MIM:610232; AllianceGenome:HGNC:24113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPH5; AFURS1
Summary
ATP13A3 is a member of the P-type ATPase family of proteins that transport a variety of cations across membranes. Other P-type ATPases include ATP7B (MIM 606882) and ATP7A (MIM 300011).[supplied by OMIM, Aug 2008]
Expression
Ubiquitous expression in thyroid (RPKM 24.7), appendix (RPKM 18.3) and 25 other tissues See more
Orthologs
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Genomic context

See ATP13A3 in Genome Data Viewer
Location:
3q29
Exon count:
41
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (194402677..194494334, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (197101099..197185515, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (194123406..194207731, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 15 Neighboring gene glycoprotein V platelet Neighboring gene ATP13A3 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 12272 Neighboring gene RNA, U6 small nuclear 1101, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ATP13A3 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90613, DKFZp686K16189

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ABC-type polyamine transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ABC-type putrescine transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables P-type transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in polyamine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in putrescine transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polyamine-transporting ATPase 13A3
Names
ATPase family homolog up-regulated in senescence cells 1
ATPase type 13A3
probable cation-transporting ATPase 13A3
putrescine transporting ATPase
NP_001354478.1
NP_001361765.1
NP_078800.3
XP_005269414.1
XP_011511423.1
XP_011511425.1
XP_011511426.1
XP_047304860.1
XP_047304861.1
XP_047304862.1
XP_047304863.1
XP_047304864.1
XP_047304865.1
XP_047304866.1
XP_047304867.1
XP_047304868.1
XP_047304869.1
XP_047304870.1
XP_047304871.1
XP_047304872.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367549.1NP_001354478.1  polyamine-transporting ATPase 13A3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC108676, AC125362
    UniProtKB/TrEMBL
    A0A2R8Y635
    Related
    ENSP00000494937.2, ENST00000645319.2
  2. NM_001374836.1NP_001361765.1  polyamine-transporting ATPase 13A3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108676, AC125362
    UniProtKB/TrEMBL
    A0A2R8YDN7
    Conserved Domains (1) summary
    TIGR01657
    Location:141122
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
  3. NM_024524.4NP_078800.3  polyamine-transporting ATPase 13A3 isoform 1

    See identical proteins and their annotated locations for NP_078800.3

    Status: VALIDATED

    Source sequence(s)
    AC108676, AK075094, AK225064, BC106085, BP313821, DA852339, DR005713, DV080200
    Consensus CDS
    CCDS43187.1
    UniProtKB/Swiss-Prot
    Q96KS1, Q9H7F0
    Related
    ENSP00000416508.1, ENST00000439040.6
    Conserved Domains (6) summary
    TIGR01657
    Location:141149
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:236483
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:178226
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12409
    Location:13145
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:622662
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:821898
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RNA

  1. NR_164666.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108676, AC125362
  2. NR_164667.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108676, AC125362

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    194402677..194494334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448912.1XP_047304868.1  polyamine-transporting ATPase 13A3 isoform X3

    UniProtKB/Swiss-Prot
    Q96KS1
    Related
    ENST00000687055.1
  2. XM_047448909.1XP_047304865.1  polyamine-transporting ATPase 13A3 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y635
  3. XM_047448904.1XP_047304860.1  polyamine-transporting ATPase 13A3 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y635
  4. XM_047448910.1XP_047304866.1  polyamine-transporting ATPase 13A3 isoform X2

    UniProtKB/TrEMBL
    A0A2R8YDN7
    Related
    ENST00000690810.1
  5. XM_047448913.1XP_047304869.1  polyamine-transporting ATPase 13A3 isoform X3

    UniProtKB/Swiss-Prot
    Q96KS1
    Related
    ENSP00000493923.2, ENST00000642744.2
  6. XM_047448916.1XP_047304872.1  polyamine-transporting ATPase 13A3 isoform X5

  7. XM_011513123.3XP_011511425.1  polyamine-transporting ATPase 13A3 isoform X3

    See identical proteins and their annotated locations for XP_011511425.1

    UniProtKB/Swiss-Prot
    Q96KS1, Q9H7F0
    Related
    ENSP00000494471.1, ENST00000645538.1
    Conserved Domains (6) summary
    TIGR01657
    Location:141149
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:236483
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:178226
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12409
    Location:13145
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:622662
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:821898
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  8. XM_047448911.1XP_047304867.1  polyamine-transporting ATPase 13A3 isoform X2

    UniProtKB/TrEMBL
    A0A2R8YDN7
  9. XM_047448914.1XP_047304870.1  polyamine-transporting ATPase 13A3 isoform X3

    UniProtKB/Swiss-Prot
    Q96KS1
  10. XM_047448906.1XP_047304862.1  polyamine-transporting ATPase 13A3 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y635
  11. XM_047448915.1XP_047304871.1  polyamine-transporting ATPase 13A3 isoform X3

    UniProtKB/Swiss-Prot
    Q96KS1
  12. XM_047448905.1XP_047304861.1  polyamine-transporting ATPase 13A3 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y635
  13. XM_047448907.1XP_047304863.1  polyamine-transporting ATPase 13A3 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y635
  14. XM_047448908.1XP_047304864.1  polyamine-transporting ATPase 13A3 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y635
  15. XM_005269357.4XP_005269414.1  polyamine-transporting ATPase 13A3 isoform X1

    See identical proteins and their annotated locations for XP_005269414.1

    UniProtKB/TrEMBL
    A0A2R8Y635
    Conserved Domains (6) summary
    TIGR01657
    Location:141149
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:236483
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:178226
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12409
    Location:13145
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:622662
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:821898
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  16. XM_011513121.2XP_011511423.1  polyamine-transporting ATPase 13A3 isoform X1

    See identical proteins and their annotated locations for XP_011511423.1

    UniProtKB/TrEMBL
    A0A2R8Y635
    Conserved Domains (6) summary
    TIGR01657
    Location:141149
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:236483
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:178226
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12409
    Location:13145
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:622662
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:821898
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  17. XM_011513124.4XP_011511426.1  polyamine-transporting ATPase 13A3 isoform X4

    Conserved Domains (6) summary
    TIGR01657
    Location:141149
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:236483
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:178226
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12409
    Location:13145
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:622662
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:821898
    HAD_like; Haloacid Dehalogenase-like Hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    197101099..197185515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)