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Sh3bp5l SH3 binding domain protein 5 like [ Mus musculus (house mouse) ]

Gene ID: 79566, updated on 5-Mar-2024

Summary

Official Symbol
Sh3bp5lprovided by MGI
Official Full Name
SH3 binding domain protein 5 likeprovided by MGI
Primary source
MGI:MGI:1933124
See related
Ensembl:ENSMUSG00000013646 AllianceGenome:MGI:1933124
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1720; 2310074E09Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and protein kinase inhibitor activity. Predicted to be involved in intracellular signal transduction and negative regulation of protein tyrosine kinase activity. Predicted to be active in cytoplasm. Orthologous to human SH3BP5L (SH3 binding domain protein 5 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 19.0), genital fat pad adult (RPKM 18.5) and 28 other tissues See more
Orthologs
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Genomic context

See Sh3bp5l in Genome Data Viewer
Location:
11 B1.3; 11 36.19 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58221533..58238554)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58330707..58347728)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39827 Neighboring gene STARR-positive B cell enhancer ABC_E2989 Neighboring gene nuclear encoded tRNA leucine 3 (anticodon CAA) Neighboring gene zinc finger protein 692 Neighboring gene STARR-positive B cell enhancer ABC_E3953 Neighboring gene zinc finger protein 672 Neighboring gene predicted gene, 33660 Neighboring gene LY6/PLAUR domain containing 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

Clone Names

  • MGC7813

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
SH3 domain-binding protein 5-like
Names
SH3BP-5-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161338.2NP_001154810.1  SH3 domain-binding protein 5-like isoform 1

    See identical proteins and their annotated locations for NP_001154810.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-3 encode the same isoform (1).
    Source sequence(s)
    AI505691, BC094418, BY125606
    Consensus CDS
    CCDS24728.1
    UniProtKB/Swiss-Prot
    Q3UMF7, Q8BUC2, Q91YX6, Q99LH9
    UniProtKB/TrEMBL
    Q80TA2
    Related
    ENSMUSP00000112077.3, ENSMUST00000116376.9
    Conserved Domains (1) summary
    pfam05276
    Location:54282
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
  2. NM_001308167.1NP_001295096.1  SH3 domain-binding protein 5-like isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AI505691, AK150129, BY125606
    UniProtKB/TrEMBL
    Q80TA2
    Conserved Domains (1) summary
    pfam05276
    Location:54280
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
  3. NM_001308168.1NP_001295097.1  SH3 domain-binding protein 5-like isoform 1

    See identical proteins and their annotated locations for NP_001295097.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1-3 encode the same isoform (1).
    Source sequence(s)
    AI505691, AK167203, BC094418, CJ153287
    Consensus CDS
    CCDS24728.1
    UniProtKB/Swiss-Prot
    Q3UMF7, Q8BUC2, Q91YX6, Q99LH9
    UniProtKB/TrEMBL
    Q80TA2
    Conserved Domains (1) summary
    pfam05276
    Location:54282
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
  4. NM_024480.5NP_077800.3  SH3 domain-binding protein 5-like isoform 1

    See identical proteins and their annotated locations for NP_077800.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-3 encode the same isoform (1).
    Source sequence(s)
    AI505691, AK159202, AK167203, BC094418, BY125606
    Consensus CDS
    CCDS24728.1
    UniProtKB/Swiss-Prot
    Q3UMF7, Q8BUC2, Q91YX6, Q99LH9
    UniProtKB/TrEMBL
    Q80TA2
    Related
    ENSMUSP00000072872.7, ENSMUST00000073128.7
    Conserved Domains (1) summary
    pfam05276
    Location:54282
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    58221533..58238554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534523.2XP_006534586.1  SH3 domain-binding protein 5-like isoform X1

    See identical proteins and their annotated locations for XP_006534586.1

    UniProtKB/Swiss-Prot
    Q3UMF7, Q8BUC2, Q91YX6, Q99LH9
    UniProtKB/TrEMBL
    Q80TA2
    Conserved Domains (1) summary
    pfam05276
    Location:54282
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)