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Acvr1 activin A receptor type 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79558, updated on 22-Aug-2021

Summary

Official Symbol
Acvr1provided by RGD
Official Full Name
activin A receptor type 1provided by RGD
Primary source
RGD:620200
See related
Ensembl:ENSRNOG00000005033
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
potential transmembrane protein serine kinase that acts as an activin receptor [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 32.9), Kidney (RPKM 31.0) and 9 other tissues See more
Orthologs
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Genomic context

See Acvr1 in Genome Data Viewer
Location:
3q21
Exon count:
18
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (42978558..43097892, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (44432476..44539680, complement)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555754 Neighboring gene cytohesin 1 interacting protein Neighboring gene activin A receptor type 1C Neighboring gene uncharacterized LOC102555913 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SMAD binding IEA
Inferred from Electronic Annotation
more info
 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables activin binding IEA
Inferred from Electronic Annotation
more info
 
enables activin binding ISO
Inferred from Sequence Orthology
more info
 
enables activin receptor activity, type I IDA
Inferred from Direct Assay
more info
PubMed 
enables activin receptor activity, type I IEA
Inferred from Electronic Annotation
more info
 
contributes_to activin receptor activity, type I ISO
Inferred from Sequence Orthology
more info
 
enables activin receptor activity, type I ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta binding IEA
Inferred from Electronic Annotation
more info
 
enables transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transforming growth factor beta receptor activity, type I IEA
Inferred from Electronic Annotation
more info
 
enables transforming growth factor beta receptor activity, type I ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane receptor protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in BMP signaling pathway involved in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in BMP signaling pathway involved in heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in atrial septum primum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in atrial septum primum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in atrioventricular valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac muscle cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucocorticoid stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in determination of left/right symmetry IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
 
involved_in dorsal/ventral pattern formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in embryonic heart tube morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic heart tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cushion cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in endocardial cushion cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cushion fusion IEA
Inferred from Electronic Annotation
more info
 
involved_in endocardial cushion fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cushion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within gastrulation ISO
Inferred from Sequence Orthology
more info
 
involved_in gastrulation with mouth forming second IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within gastrulation with mouth forming second ISO
Inferred from Sequence Orthology
more info
 
involved_in germ cell development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within germ cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesoderm development ISO
Inferred from Sequence Orthology
more info
 
involved_in mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mesoderm formation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitral valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in mitral valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural crest cell migration ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in pathway-restricted SMAD protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in pharyngeal system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pharyngeal system development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of determination of dorsal identity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of determination of dorsal identity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of skeletal muscle tissue development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within urogenital system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of BMP receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of activin receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of activin receptor complex IEA
Inferred from Electronic Annotation
more info
 
part_of activin receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
activin receptor type-1
Names
ACTR-I
ALK2-B
SKR1
TGF-B superfamily receptor type I
TSR-I
activin A receptor, type I
activin receptor type I
activin type I receptor
serine/threonine-protein kinase receptor R1
NP_077812.1
XP_008760089.1
XP_017447543.1
XP_038961824.1
XP_038961825.1
XP_038961826.1
XP_038961827.1
XP_038961828.1
XP_038961830.1
XP_038961831.1
XP_038961832.1
XP_038961833.1
XP_038961834.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024486.1NP_077812.1  activin receptor type-1 precursor

    See identical proteins and their annotated locations for NP_077812.1

    Status: PROVISIONAL

    Source sequence(s)
    L19341
    UniProtKB/Swiss-Prot
    P80201
    UniProtKB/TrEMBL
    B3DM96
    Conserved Domains (3) summary
    cd14142
    Location:202499
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:37102
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:179206
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    42978558..43097892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105905.1XP_038961833.1  activin receptor type-1 isoform X3

    Conserved Domains (3) summary
    cd14142
    Location:202499
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:37102
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:179206
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  2. XM_039105903.1XP_038961831.1  activin receptor type-1 isoform X1

    Conserved Domains (3) summary
    cd14142
    Location:221518
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:56121
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:198225
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  3. XM_039105904.1XP_038961832.1  activin receptor type-1 isoform X3

    Conserved Domains (3) summary
    cd14142
    Location:202499
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:37102
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:179206
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  4. XM_039105896.1XP_038961824.1  activin receptor type-1 isoform X1

    Conserved Domains (3) summary
    cd14142
    Location:221518
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:56121
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:198225
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  5. XM_039105906.1XP_038961834.1  activin receptor type-1 isoform X4

    Conserved Domains (3) summary
    cd14142
    Location:185482
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:2085
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:162189
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  6. XM_008761867.2XP_008760089.1  activin receptor type-1 isoform X2

    Conserved Domains (4) summary
    smart00220
    Location:211495
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14142
    Location:204501
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:35104
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:181208
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  7. XM_039105899.1XP_038961827.1  activin receptor type-1 isoform X1

    Conserved Domains (3) summary
    cd14142
    Location:221518
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:56121
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:198225
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  8. XM_039105897.1XP_038961825.1  activin receptor type-1 isoform X1

    Conserved Domains (3) summary
    cd14142
    Location:221518
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:56121
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:198225
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  9. XM_039105900.1XP_038961828.1  activin receptor type-1 isoform X1

    Conserved Domains (3) summary
    cd14142
    Location:221518
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:56121
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:198225
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  10. XM_039105898.1XP_038961826.1  activin receptor type-1 isoform X1

    Conserved Domains (3) summary
    cd14142
    Location:221518
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:56121
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:198225
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  11. XM_039105902.1XP_038961830.1  activin receptor type-1 isoform X1

    Conserved Domains (3) summary
    cd14142
    Location:221518
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:56121
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:198225
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  12. XM_017592054.2XP_017447543.1  activin receptor type-1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2P7
    Related
    ENSRNOP00000072326.1
    Conserved Domains (3) summary
    cd14142
    Location:221518
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:56121
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:198225
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
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