Format

Send to:

Choose Destination

Chrna1 cholinergic receptor nicotinic alpha 1 subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 79557, updated on 19-Apr-2019

Summary

Official Symbol
Chrna1provided by RGD
Official Full Name
cholinergic receptor nicotinic alpha 1 subunitprovided by RGD
Primary source
RGD:69277
See related
Ensembl:ENSRNOG00000018286
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
alpha subunit of the AChR gamma and AChR epsilon acetylcholine receptor subtypes [RGD, Feb 2006]
Expression
Biased expression in Muscle (RPKM 33.4), Heart (RPKM 3.8) and 1 other tissue See more
Orthologs

Genomic context

See Chrna1 in Genome Data Viewer
Location:
3q23
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (60445657..60460724, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (66925891..66940958, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC103691822 Neighboring gene uncharacterized LOC108350398 Neighboring gene uncharacterized LOC102552170 Neighboring gene uncharacterized LOC102552328 Neighboring gene chimerin 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
cation transport IDA
Inferred from Direct Assay
more info
PubMed 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle cell cellular homeostasis IEA
Inferred from Electronic Annotation
more info
 
muscle cell cellular homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
musculoskeletal movement ISO
Inferred from Sequence Orthology
more info
PubMed 
nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuromuscular junction development IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
PubMed 
neuromuscular process IEA
Inferred from Electronic Annotation
more info
 
neuromuscular process ISO
Inferred from Sequence Orthology
more info
PubMed 
neuromuscular synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuromuscular synaptic transmission ISO
Inferred from Sequence Orthology
more info
PubMed 
neuron cellular homeostasis IEA
Inferred from Electronic Annotation
more info
 
neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
neuronal action potential IEA
Inferred from Electronic Annotation
more info
 
neuronal action potential ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
PubMed 
response to nicotine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
skeletal muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
PubMed 
skeletal muscle tissue growth IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle tissue growth ISO
Inferred from Sequence Orthology
more info
PubMed 
synaptic transmission, cholinergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
PubMed 
acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
PubMed 
acetylcholine-gated channel complex TAS
Traceable Author Statement
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction ISO
Inferred from Sequence Orthology
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
acetylcholine receptor subunit alpha
Names
cholinergic receptor nicotinic alpha polypeptide 1
cholinergic receptor, nicotinic, alpha 1 (muscle)
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024485.1NP_077811.1  acetylcholine receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_077811.1

    Status: PROVISIONAL

    Source sequence(s)
    X74832
    UniProtKB/Swiss-Prot
    P25108
    Related
    ENSRNOP00000024706.3, ENSRNOT00000024706.4
    Conserved Domains (3) summary
    TIGR00860
    Location:21447
    LIC; Cation transporter family protein
    pfam02931
    Location:24231
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:238446
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    60445657..60460724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    57981902..57996970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center