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OR2A4 olfactory receptor family 2 subfamily A member 4 [ Homo sapiens (human) ]

Gene ID: 79541, updated on 25-Jan-2022

Summary

Official Symbol
OR2A4provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily A member 4provided by HGNC
Primary source
HGNC:HGNC:14729
See related
Ensembl:ENSG00000180658 AllianceGenome:HGNC:14729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR2A10
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
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Genomic context

See OR2A4 in Genome Data Viewer
Location:
6q23.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (131699644..131701401, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132020784..132022541, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 23 Neighboring gene arginase 1 Neighboring gene RNA, U4 small nuclear 18, pseudogene Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 3 Neighboring gene CTAGE family member 9 Neighboring gene ribosomal protein L15 pseudogene 9

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Flemming body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitotic spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
olfactory receptor 2A4
Names
olfactory receptor 2A10
olfactory receptor OR6-37
olfactory receptor, family 2, subfamily A, member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030908.2NP_112170.1  olfactory receptor 2A4

    See identical proteins and their annotated locations for NP_112170.1

    Status: VALIDATED

    Source sequence(s)
    AW863744, BC120953, BF848491, BI020419, CB852924, DA927334
    Consensus CDS
    CCDS5149.1
    UniProtKB/Swiss-Prot
    O95047
    UniProtKB/TrEMBL
    A0A126GVW2
    Related
    ENSP00000319546.2, ENST00000315453.4
    Conserved Domains (2) summary
    cd14964
    Location:2650
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:24300
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    131699644..131701401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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