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S100G S100 calcium binding protein G [ Homo sapiens (human) ]

Gene ID: 795, updated on 1-Jun-2020

Summary

Official Symbol
S100Gprovided by HGNC
Official Full Name
S100 calcium binding protein Gprovided by HGNC
Primary source
HGNC:HGNC:1436
See related
Ensembl:ENSG00000169906 MIM:302020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CABP; CABP1; CALB3; CABP9K
Summary
This gene encodes calbindin D9K, a vitamin D-dependent calcium-binding protein. This cytosolic protein belongs to a family of calcium-binding proteins that includes calmodulin, parvalbumin, troponin C, and S100 protein. In the intestine, the protein is vitamin D-dependent and its expression correlates with calcium transport activity. The protein may increase Ca2+ absorption by buffering Ca2+ in the cytoplasm and increase ATP-dependent Ca2+ transport in duodenal basolateral membrane vesicles. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward duodenum (RPKM 36.4) See more
Orthologs

Genomic context

See S100G in Genome Data Viewer
Location:
Xp22.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (16649787..16654674)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (16668281..16672791)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 658, pseudogene Neighboring gene CTP synthase 2 Neighboring gene microRNA 548am Neighboring gene synapse associated protein 1 Neighboring gene RNA, U7 small nuclear 56 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138379

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 
vitamin D binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein S100-G
Names
calbindin 3, (vitamin D-dependent calcium-binding protein)
calbindin D9K
calbindin-D9k
vitamin D-dependent calcium-binding protein, intestinal

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004057.3NP_004048.1  protein S100-G

    See identical proteins and their annotated locations for NP_004048.1

    Status: REVIEWED

    Source sequence(s)
    AL445467, L13220
    Consensus CDS
    CCDS14176.1
    UniProtKB/Swiss-Prot
    P29377
    Related
    ENSP00000369547.3, ENST00000380200.3
    Conserved Domains (1) summary
    cd00213
    Location:1279
    S-100; S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    16649787..16654674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029841.1XP_016885330.1  protein S100-G isoform X1

    UniProtKB/Swiss-Prot
    P29377
    Conserved Domains (1) summary
    cd00213
    Location:1279
    S-100; S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...
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