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ULBP3 UL16 binding protein 3 [ Homo sapiens (human) ]

Gene ID: 79465, updated on 8-Jul-2021

Summary

Official Symbol
ULBP3provided by HGNC
Official Full Name
UL16 binding protein 3provided by HGNC
Primary source
HGNC:HGNC:14895
See related
Ensembl:ENSG00000131019 MIM:605699
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
N2DL-3; RAET1N; NKG2DL3
Summary
The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. [provided by RefSeq, Nov 2015]
Expression
Broad expression in testis (RPKM 3.9), thyroid (RPKM 2.5) and 17 other tissues See more
Orthologs
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Genomic context

See ULBP3 in Genome Data Viewer
Location:
6q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (150061053..150069121, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (150382189..150390257, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene retinoic acid early transcript 1M pseudogene Neighboring gene prohibitin pseudogene 1 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14C Neighboring gene VISTA enhancer hs1922 Neighboring gene uncharacterized LOC105378054 Neighboring gene CRISPRi-validated cis-regulatory element chr6.5240

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
GeneReviews: Not available
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif A3G upregulates NKG2D ligands through an ATM pathway and in which HIV-1 Vif counteracts this upregulation by decreasing A3G expression PubMed
vif Vpr-dependent induction and Vif-mediated attenuation of NKG2D ligands are required for Chk2 phosphorylation in HIV infection PubMed
vif HIV-1 Vif expression in HIV-1 infected cells results in less HIV-1 Vpr-dependent upregulation of NKG2D ligands PubMed
Vpr vpr HIV-1-Vpr induced upregulation of NKG2D ligands in HIV-infected T cells by activating UNG2-dependent repair of uridine-containing DNA PubMed
vpr HIV-1 Vpr upregulates NKG2D ligands via the ATR pathway PubMed
vpr Vpr-dependent induction and Vif-mediated attenuation of NKG2D ligands are required for Chk2 phosphorylation in HIV infection PubMed
vpr HIV-1 Vif expression in HIV-1 infected cells results in less HIV-1 Vpr-dependent upregulation of NKG2D ligands PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables natural killer cell lectin-like receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in natural killer cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in anchored component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
UL16-binding protein 3
Names
ALCAN-gamma
NKG2D ligand 3
retinoic acid early transcript 1N

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024518.3NP_078794.1  UL16-binding protein 3

    See identical proteins and their annotated locations for NP_078794.1

    Status: REVIEWED

    Source sequence(s)
    AK315275, AL355497, CA488356
    Consensus CDS
    CCDS5225.1
    UniProtKB/Swiss-Prot
    Q9BZM4
    Related
    ENSP00000356308.1, ENST00000367339.7
    Conserved Domains (1) summary
    cl08246
    Location:32206
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    150061053..150069121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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