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PAGR1 PAXIP1 associated glutamate rich protein 1 [ Homo sapiens (human) ]

Gene ID: 79447, updated on 9-Feb-2020

Summary

Official Symbol
PAGR1provided by HGNC
Official Full Name
PAXIP1 associated glutamate rich protein 1provided by HGNC
Primary source
HGNC:HGNC:28707
See related
Ensembl:ENSG00000280789 MIM:612033
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAS; PA1; C16orf53
Summary
C16ORF53 (PA1) is a component of a Set1-like multiprotein histone methyltransferase complex (Cho et al., 2007 [PubMed 17500065]).[supplied by OMIM, May 2008]
Expression
Ubiquitous expression in ovary (RPKM 11.5), prostate (RPKM 9.7) and 25 other tissues See more
Orthologs

Genomic context

See PAGR1 in Genome Data Viewer
Location:
16p11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (29816152..29822489)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29827528..29833816)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268170 Neighboring gene MYC associated zinc finger protein Neighboring gene proline rich transmembrane protein 2 Neighboring gene major vault protein Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase Neighboring gene CDIP transferase opposite strand, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4606, FLJ22459

Gene Ontology Provided by GOA

Function Evidence Code Pubs
estrogen receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
estrogen receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
histone H3-K4 methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell cycle G1/S phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell cycle G1/S phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular estrogen receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of intracellular estrogen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
MLL3/4 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MLL3/4 complex IDA
Inferred from Direct Assay
more info
PubMed 
histone methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
PAXIP1-associated glutamate-rich protein 1
Names
PAXIP1-associated protein 1
PTIP-associated 1 protein
PTIP-associated protein 1
glutamate-rich coactivator associated with SRC1
glutamate-rich coactivator interacting with SRC1
glutamate-rich coactivator interacting with SRC1/NCOA1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024516.4NP_078792.1  PAXIP1-associated glutamate-rich protein 1

    See identical proteins and their annotated locations for NP_078792.1

    Status: VALIDATED

    Source sequence(s)
    AC009133, AC120114, AL549915, BC003640, CA455544
    Consensus CDS
    CCDS10655.1
    UniProtKB/Swiss-Prot
    Q9BTK6
    Related
    ENSP00000326519.6, ENST00000320330.8
    Conserved Domains (1) summary
    pfam15364
    Location:86217
    PAXIP1_C; PAXIP1-associated-protein-1 C term PTIP binding protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    29816152..29822489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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