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BIRC7 baculoviral IAP repeat containing 7 [ Homo sapiens (human) ]

Gene ID: 79444, updated on 22-Sep-2022

Summary

Official Symbol
BIRC7provided by HGNC
Official Full Name
baculoviral IAP repeat containing 7provided by HGNC
Primary source
HGNC:HGNC:13702
See related
Ensembl:ENSG00000101197 MIM:605737; AllianceGenome:HGNC:13702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAP; LIVIN; MLIAP; RNF50; ML-IAP
Summary
This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013]
Expression
Biased expression in placenta (RPKM 3.1), skin (RPKM 0.7) and 5 other tissues See more
Orthologs
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Genomic context

See BIRC7 in Genome Data Viewer
Location:
20q13.33
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (63235905..63240495)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65041919..65046510)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61867257..61871847)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene microRNA 124-3 Neighboring gene Sharpr-MPRA regulatory region 12386 Neighboring gene YTH N6-methyladenosine RNA binding protein 1 Neighboring gene uncharacterized LOC124904950 Neighboring gene microRNA 3196 Neighboring gene sodium/potassium transporting ATPase interacting 4 Neighboring gene uncharacterized LOC100192386

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enzyme binding NAS
Non-traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lens development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_negative_effect regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of natural killer cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
baculoviral IAP repeat-containing protein 7
Names
RING finger protein 50
RING-type E3 ubiquitin transferase BIRC7
kidney inhibitor of apoptosis protein
livin inhibitor of apoptosis
melanoma inhibitor of apoptosis protein
NP_071444.1
NP_647478.1
XP_047296451.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029552.1 RefSeqGene

    Range
    4982..9572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022161.4NP_071444.1  baculoviral IAP repeat-containing protein 7 isoform beta

    See identical proteins and their annotated locations for NP_071444.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (beta) is shorter, compared to isoform alpha. Isoform beta protects cells from etoposide-induced apoptosis.
    Source sequence(s)
    AY358835, BU737800
    Consensus CDS
    CCDS13512.1
    UniProtKB/Swiss-Prot
    Q96CA5
    Related
    ENSP00000345213.6, ENST00000342412.10
    Conserved Domains (2) summary
    cd00022
    Location:88155
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    pfam13920
    Location:230274
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  2. NM_139317.3NP_647478.1  baculoviral IAP repeat-containing protein 7 isoform alpha

    See identical proteins and their annotated locations for NP_647478.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (alpha). Isoform alpha protects cells from staurosporine-induced apoptosis.
    Source sequence(s)
    AY358836
    Consensus CDS
    CCDS13513.1
    UniProtKB/Swiss-Prot
    Q96CA5, Q9HAP7
    Related
    ENSP00000217169.3, ENST00000217169.8
    Conserved Domains (2) summary
    cd00022
    Location:88155
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    pfam13920
    Location:248292
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    63235905..63240495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440495.1XP_047296451.1  baculoviral IAP repeat-containing protein 7 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    65041919..65046510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)