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FYCO1 FYVE and coiled-coil domain autophagy adaptor 1 [ Homo sapiens (human) ]

Gene ID: 79443, updated on 4-Jul-2021

Summary

Official Symbol
FYCO1provided by HGNC
Official Full Name
FYVE and coiled-coil domain autophagy adaptor 1provided by HGNC
Primary source
HGNC:HGNC:14673
See related
Ensembl:ENSG00000163820 MIM:607182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CATC2; RUFY3; ZFYVE7; CTRCT18
Summary
The gene encodes a Rab7 adapter protein that is implicated in the microtubule transport of autophagosomes. The encoded protein contains a RUN domain, a FYVE-type zinc finger domain, and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P), the autophagosome marker LC3, and the kinesin KIF5. Mutations in this gene are associated with inclusion body myositis (IBM) and autosomal recessive congenital cataracts (CATC2). [provided by RefSeq, Aug 2020]
Expression
Ubiquitous expression in heart (RPKM 22.7), endometrium (RPKM 12.6) and 25 other tissues See more
Orthologs
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Genomic context

See FYCO1 in Genome Data Viewer
Location:
3p21.31
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (45917903..45995824, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (45959395..46037316, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene leucine zipper transcription factor like 1 Neighboring gene CCR9 promoter region Neighboring gene succinate dehydrogenase complex subunit D pseudogene 4 Neighboring gene C-C motif chemokine receptor 9 Neighboring gene C-X-C motif chemokine receptor 6 Neighboring gene Sharpr-MPRA regulatory region 2695 Neighboring gene uncharacterized LOC105377063 Neighboring gene nuclear receptor binding factor 2 pseudogene 2 Neighboring gene X-C motif chemokine receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13335, MGC126517, MGC126519, DKFZp779K1152

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 

General protein information

Preferred Names
FYVE and coiled-coil domain-containing protein 1
Names
FYVE and coiled-coil domain containing 1
RUN and FYVE domain containing 3
zinc finger FYVE domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031955.1 RefSeqGene

    Range
    5001..82922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001386421.1NP_001373350.1  FYVE and coiled-coil domain-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC099782
    Conserved Domains (5) summary
    PRK11281
    Location:9781164
    PRK11281; mechanosensitive channel MscK
    TIGR02168
    Location:2431050
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15726
    Location:11701227
    FYVE_FYCO1; FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins
    pfam13897
    Location:14191464
    GOLD_2; Golgi-dynamics membrane-trafficking
    cl02689
    Location:59164
    RUN; RUN domain
  2. NM_001386422.1NP_001373351.1  FYVE and coiled-coil domain-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC099782
    Conserved Domains (5) summary
    PRK11281
    Location:9781164
    PRK11281; mechanosensitive channel MscK
    TIGR02168
    Location:2431050
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15726
    Location:11701227
    FYVE_FYCO1; FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins
    pfam13897
    Location:14191464
    GOLD_2; Golgi-dynamics membrane-trafficking
    cl02689
    Location:59164
    RUN; RUN domain
  3. NM_001386423.1NP_001373352.1  FYVE and coiled-coil domain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC099782
    Conserved Domains (5) summary
    PRK11281
    Location:9781164
    PRK11281; mechanosensitive channel MscK
    TIGR02168
    Location:2431050
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15726
    Location:11701227
    FYVE_FYCO1; FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins
    pfam13897
    Location:14181463
    GOLD_2; Golgi-dynamics membrane-trafficking
    cl02689
    Location:59164
    RUN; RUN domain
  4. NM_001386424.1NP_001373353.1  FYVE and coiled-coil domain-containing protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC099782
    Conserved Domains (4) summary
    PRK11281
    Location:9781164
    PRK11281; mechanosensitive channel MscK
    TIGR02168
    Location:2431050
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15726
    Location:11701227
    FYVE_FYCO1; FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins
    cl02689
    Location:59164
    RUN; RUN domain
  5. NM_001386425.1NP_001373354.1  FYVE and coiled-coil domain-containing protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC099782
    Conserved Domains (4) summary
    PRK11281
    Location:9781164
    PRK11281; mechanosensitive channel MscK
    TIGR02168
    Location:2431050
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15726
    Location:11701227
    FYVE_FYCO1; FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins
    cl02689
    Location:59164
    RUN; RUN domain
  6. NM_001386426.1NP_001373355.1  FYVE and coiled-coil domain-containing protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC099782
    Conserved Domains (5) summary
    PRK11281
    Location:9381124
    PRK11281; mechanosensitive channel MscK
    TIGR02168
    Location:2031010
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15726
    Location:11301187
    FYVE_FYCO1; FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins
    pfam13897
    Location:13791424
    GOLD_2; Golgi-dynamics membrane-trafficking
    cl02689
    Location:19124
    RUN; RUN domain
  7. NM_001386427.1NP_001373356.1  FYVE and coiled-coil domain-containing protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC099782
    Conserved Domains (5) summary
    PRK11281
    Location:9301116
    PRK11281; mechanosensitive channel MscK
    TIGR02168
    Location:1951002
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15726
    Location:11221179
    FYVE_FYCO1; FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins
    pfam13897
    Location:13711416
    GOLD_2; Golgi-dynamics membrane-trafficking
    cl02689
    Location:59124
    RUN; RUN domain
  8. NM_001386428.1NP_001373357.1  FYVE and coiled-coil domain-containing protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC099782
    Conserved Domains (4) summary
    PRK11281
    Location:9781164
    PRK11281; mechanosensitive channel MscK
    TIGR02168
    Location:2431050
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15726
    Location:11701227
    FYVE_FYCO1; FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins
    cl02689
    Location:59164
    RUN; RUN domain
  9. NM_001386429.1NP_001373358.1  FYVE and coiled-coil domain-containing protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC099782
    Conserved Domains (4) summary
    PRK11281
    Location:9781164
    PRK11281; mechanosensitive channel MscK
    TIGR02168
    Location:2431050
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15726
    Location:11701227
    FYVE_FYCO1; FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins
    cl02689
    Location:59164
    RUN; RUN domain
  10. NM_001386430.1NP_001373359.1  FYVE and coiled-coil domain-containing protein 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC099782
    Conserved Domains (4) summary
    PRK11281
    Location:778964
    PRK11281; mechanosensitive channel MscK
    TIGR02168
    Location:43850
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15726
    Location:9701027
    FYVE_FYCO1; FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins
    pfam13897
    Location:12191264
    GOLD_2; Golgi-dynamics membrane-trafficking
  11. NM_024513.4NP_078789.2  FYVE and coiled-coil domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_078789.2

    Status: REVIEWED

    Source sequence(s)
    AC099782, BC101468, DB134257
    Consensus CDS
    CCDS2734.1
    UniProtKB/Swiss-Prot
    Q9BQS8
    Related
    ENSP00000296137.2, ENST00000296137.7
    Conserved Domains (5) summary
    PRK11281
    Location:9781164
    PRK11281; mechanosensitive channel MscK
    TIGR02168
    Location:2431050
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15726
    Location:11701227
    FYVE_FYCO1; FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins
    pfam13897
    Location:14191464
    GOLD_2; Golgi-dynamics membrane-trafficking
    cl02689
    Location:59164
    RUN; RUN domain

RNA

  1. NR_170107.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC099782

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    45917903..45995824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713333.3XP_006713396.1  FYVE and coiled-coil domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006713396.1

    UniProtKB/Swiss-Prot
    Q9BQS8
    Conserved Domains (5) summary
    PRK11281
    Location:9781164
    PRK11281; mechanosensitive channel MscK
    TIGR02168
    Location:2431050
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15726
    Location:11701227
    FYVE_FYCO1; FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins
    pfam13897
    Location:14191464
    GOLD_2; Golgi-dynamics membrane-trafficking
    cl02689
    Location:59164
    RUN; RUN domain

RNA

  1. XR_001740265.1 RNA Sequence

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