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HAUS3 HAUS augmin like complex subunit 3 [ Homo sapiens (human) ]

Gene ID: 79441, updated on 19-Dec-2019

Summary

Official Symbol
HAUS3provided by HGNC
Official Full Name
HAUS augmin like complex subunit 3provided by HGNC
Primary source
HGNC:HGNC:28719
See related
Ensembl:ENSG00000214367 MIM:613430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IT1; dgt3; C4orf15
Summary
This gene encodes a component of the HAUS augmin-like protein complex, which plays a key role in cytokinesis and mitosis. Disruption of the encoded protein causes mitotic defects resulting from fragmentation of centrosomes and microtubule destabilization. This gene shares its 5' exons with some transcripts from overlapping GeneID: 353497, which encodes a DNA polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in bone marrow (RPKM 19.8), lymph node (RPKM 8.7) and 24 other tissues See more
Orthologs

Genomic context

See HAUS3 in Genome Data Viewer
Location:
4p16.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (2228349..2242121, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (2230096..2243860, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase 8 like Neighboring gene HBS1 like translational GTPase pseudogene Neighboring gene DNA polymerase nu Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 5 Neighboring gene CRISPRi-validated cis-regulatory element chr4.319 Neighboring gene microRNA 4800 Neighboring gene MAX dimerization protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4701, DKFZp686I1868

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
HAUS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
HAUS complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
HAUS augmin-like complex subunit 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303143.2NP_001290072.1  HAUS augmin-like complex subunit 3

    See identical proteins and their annotated locations for NP_001290072.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL158068, BC003648, BF508642
    Consensus CDS
    CCDS33941.1
    UniProtKB/Swiss-Prot
    Q68CZ6
    Related
    ENSP00000392903.2, ENST00000443786.2
    Conserved Domains (1) summary
    pfam14932
    Location:29281
    HAUS-augmin3; HAUS augmin-like complex subunit 3
  2. NM_024511.7NP_078787.2  HAUS augmin-like complex subunit 3

    See identical proteins and their annotated locations for NP_078787.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF040964, AL158068, BF508642, CR749640
    Consensus CDS
    CCDS33941.1
    UniProtKB/Swiss-Prot
    Q68CZ6
    Related
    ENSP00000243706.4, ENST00000243706.8
    Conserved Domains (1) summary
    pfam14932
    Location:29281
    HAUS-augmin3; HAUS augmin-like complex subunit 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    2228349..2242121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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