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Igfals insulin-like growth factor binding protein, acid labile subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 79438, updated on 30-Sep-2021

Summary

Official Symbol
Igfalsprovided by RGD
Official Full Name
insulin-like growth factor binding protein, acid labile subunitprovided by RGD
Primary source
RGD:68429
See related
EnsemblRapid:ENSRNOG00000015061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Als
Summary
subunit of the ternary insulin-like growth factor-binding protein complex; involved in controlling the bioavailability of circulating insulin-like growth factors [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 342.9) and Kidney (RPKM 47.2) See more
Orthologs
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Genomic context

See Igfals in Genome Data Viewer
Location:
10q12
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13897468..13903920)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14240308..14243554)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene transfer RNA proline (anticodon AGG) Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene nucleotide binding protein 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene essential meiotic structure-specific endonuclease subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables insulin-like growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-like growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to epidermal growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to growth hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of insulin-like growth factor ternary complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of insulin-like growth factor ternary complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of insulin-like growth factor ternary complex IEA
Inferred from Electronic Annotation
more info
 
part_of insulin-like growth factor ternary complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
insulin-like growth factor-binding protein complex acid labile subunit
Names
insulin-like growth factor-binding protein complex acid labile chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053329.3NP_445781.3  insulin-like growth factor-binding protein complex acid labile subunit precursor

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000219
    Related
    ENSRNOP00000020233.5, ENSRNOT00000020233.6
    Conserved Domains (5) summary
    smart00013
    Location:4078
    LRRNT; Leucine rich repeat N-terminal domain
    PLN00113
    Location:68494
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:244267
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:486536
    LRR_8; Leucine rich repeat
    cl15307
    Location:535578
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    13897468..13903920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086922.1XP_038942850.1  insulin-like growth factor-binding protein complex acid labile subunit isoform X1

    Related
    ENSRNOP00000077501.1, ENSRNOT00000096529.1
    Conserved Domains (5) summary
    smart00013
    Location:4078
    LRRNT; Leucine rich repeat N-terminal domain
    PLN00113
    Location:68494
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:244267
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:486536
    LRR_8; Leucine rich repeat
    cl15307
    Location:535578
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
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