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Igfals insulin-like growth factor binding protein, acid labile subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 79438, updated on 23-May-2018
Official Symbol
Igfalsprovided by RGD
Official Full Name
insulin-like growth factor binding protein, acid labile subunitprovided by RGD
Primary source
RGD:68429
See related
Ensembl:ENSRNOG00000015061
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Als
Summary
subunit of the ternary insulin-like growth factor-binding protein complex; involved in controlling the bioavailability of circulating insulin-like growth factors [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in Liver (RPKM 342.9) and Kidney (RPKM 47.2) See more
Orthologs
See Igfals in Genome Data Viewer
Location:
10q12
Exon count:
2
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14240308..14243554)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (14056324..14059570)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene meiosis specific with OB domains Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene nucleotide binding protein 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene essential meiotic structure-specific endonuclease subunit 2

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
insulin-like growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to epidermal growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to growth hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
insulin-like growth factor ternary complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor ternary complex IDA
Inferred from Direct Assay
more info
PubMed 
insulin-like growth factor ternary complex IEA
Inferred from Electronic Annotation
more info
 
insulin-like growth factor ternary complex ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
insulin-like growth factor-binding protein complex acid labile subunit
Names
insulin-like growth factor-binding protein complex acid labile chain

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053329.2NP_445781.2  insulin-like growth factor-binding protein complex acid labile subunit precursor

    See identical proteins and their annotated locations for NP_445781.2

    Status: PROVISIONAL

    Source sequence(s)
    S46785
    UniProtKB/Swiss-Prot
    P35859
    Related
    ENSRNOP00000020233.5, ENSRNOT00000020233.5
    Conserved Domains (5) summary
    smart00013
    Location:4078
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:286537
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:244267
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:219278
    LRR_8; Leucine rich repeat
    cl15307
    Location:535578
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    14240308..14243554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    13578539..13581785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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