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Clcnkb chloride voltage-gated channel Kb [ Rattus norvegicus (Norway rat) ]

Gene ID: 79430, updated on 2-Oct-2018

Summary

Official Symbol
Clcnkbprovided by RGD
Official Full Name
chloride voltage-gated channel Kbprovided by RGD
Primary source
RGD:628639
See related
Ensembl:ENSRNOG00000009897
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Clck2; ClC-K2L; Clcnk1l
Summary
This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 5. This gene is syntenic with human CLCNKA (geneID:1187).[provided by RefSeq, Sep 2009]
Expression
Biased expression in Kidney (RPKM 404.0) and Heart (RPKM 28.1) See more

Genomic context

See Clcnkb in Genome Data Viewer
Location:
5q36
Exon count:
22
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (159950384..159973576, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (163670926..163694123, complement)

Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 131, member C Neighboring gene chloride voltage-gated channel Ka Neighboring gene heat shock protein family B (small) member 7 Neighboring gene steroid receptor associated and regulated protein Neighboring gene zinc finger and BTB domain containing 17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
chloride channel activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
voltage-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
transepithelial chloride transport NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
chloride channel protein ClC-Kb
Names
chloride channel K2
chloride channel Kb
chloride channel, voltage-sensitive Kb
clC-K2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173103.1NP_775126.1  chloride channel protein ClC-Kb

    See identical proteins and their annotated locations for NP_775126.1

    Status: PROVISIONAL

    Source sequence(s)
    Z30663
    UniProtKB/Swiss-Prot
    P51802
    Related
    ENSRNOP00000013550.2, ENSRNOT00000013550.5
    Conserved Domains (3) summary
    cd03683
    Location:49533
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    pfam00571
    Location:547604
    CBS; CBS domain
    pfam00654
    Location:106513
    Voltage_CLC; Voltage gated chloride channel

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

    Range
    159950384..159973576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764293.2XP_008762515.1  chloride channel protein ClC-Kb isoform X1

    See identical proteins and their annotated locations for XP_008762515.1

    UniProtKB/TrEMBL
    G3V7B3
    Conserved Domains (3) summary
    cd03683
    Location:49533
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    pfam00571
    Location:547604
    CBS; CBS domain
    pfam00654
    Location:106513
    Voltage_CLC; Voltage gated chloride channel
  2. XM_006239320.3XP_006239382.1  chloride channel protein ClC-Kb isoform X1

    See identical proteins and their annotated locations for XP_006239382.1

    UniProtKB/TrEMBL
    G3V7B3
    Conserved Domains (3) summary
    cd03683
    Location:49533
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    pfam00571
    Location:547604
    CBS; CBS domain
    pfam00654
    Location:106513
    Voltage_CLC; Voltage gated chloride channel
  3. XM_017593656.1XP_017449145.1  chloride channel protein ClC-Kb isoform X4

  4. XM_008764294.2XP_008762516.1  chloride channel protein ClC-Kb isoform X1

    See identical proteins and their annotated locations for XP_008762516.1

    UniProtKB/TrEMBL
    G3V7B3
    Conserved Domains (3) summary
    cd03683
    Location:49533
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    pfam00571
    Location:547604
    CBS; CBS domain
    pfam00654
    Location:106513
    Voltage_CLC; Voltage gated chloride channel
  5. XM_008764297.2XP_008762519.1  chloride channel protein ClC-Kb isoform X3

    UniProtKB/TrEMBL
    E9PTA8
    Related
    ENSRNOP00000049598.4, ENSRNOT00000050729.4
    Conserved Domains (3) summary
    cd03683
    Location:49490
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    pfam00654
    Location:59470
    Voltage_CLC; Voltage gated chloride channel
    cl15354
    Location:512633
    CBS_pair; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  6. XM_008764296.2XP_008762518.1  chloride channel protein ClC-Kb isoform X2

    Conserved Domains (3) summary
    cd03683
    Location:49496
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    pfam00571
    Location:510567
    CBS; CBS domain
    pfam00654
    Location:106476
    Voltage_CLC; Voltage gated chloride channel
  7. XM_008764295.2XP_008762517.1  chloride channel protein ClC-Kb isoform X1

    See identical proteins and their annotated locations for XP_008762517.1

    UniProtKB/TrEMBL
    G3V7B3
    Conserved Domains (3) summary
    cd03683
    Location:49533
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    pfam00571
    Location:547604
    CBS; CBS domain
    pfam00654
    Location:106513
    Voltage_CLC; Voltage gated chloride channel
  8. XM_017593655.1XP_017449144.1  chloride channel protein ClC-Kb isoform X4

Alternate Rn_Celera

Genomic

  1. AC_000073.1 Alternate Rn_Celera

    Range
    152071911..152083591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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