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LRFN3 leucine rich repeat and fibronectin type III domain containing 3 [ Homo sapiens (human) ]

Gene ID: 79414, updated on 23-Nov-2021

Summary

Official Symbol
LRFN3provided by HGNC
Official Full Name
leucine rich repeat and fibronectin type III domain containing 3provided by HGNC
Primary source
HGNC:HGNC:28370
See related
Ensembl:ENSG00000126243 MIM:612809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SALM4; FIGLER1
Expression
Ubiquitous expression in brain (RPKM 3.2), fat (RPKM 3.1) and 24 other tissues See more
Orthologs
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Genomic context

See LRFN3 in Genome Data Viewer
Location:
19q13.12
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35936374..35946624)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36427276..36437526)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transmembrane immune signaling adaptor TYROBP Neighboring gene hematopoietic cell signal transducer Neighboring gene uncharacterized LOC105372383 Neighboring gene Sharpr-MPRA regulatory region 1826 Neighboring gene succinate dehydrogenase complex assembly factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC2656

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of presynapse assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic membrane adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic membrane adhesion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
leucine-rich repeat and fibronectin type-III domain-containing protein 3
Names
fibronectin type III, immunoglobulin and leucine rich repeat domains 1
synaptic adhesion-like molecule 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024509.2NP_078785.1  leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor

    See identical proteins and their annotated locations for NP_078785.1

    Status: VALIDATED

    Source sequence(s)
    AF038458, BC003578
    Consensus CDS
    CCDS12483.1
    UniProtKB/Swiss-Prot
    Q9BTN0
    Related
    ENSP00000246529.3, ENST00000246529.4
    Conserved Domains (8) summary
    smart00410
    Location:302383
    IG_like; Immunoglobulin like
    cd00116
    Location:63168
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:242253
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:6384
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:424502
    fn3; Fibronectin type III domain
    pfam13855
    Location:59119
    LRR_8; Leucine rich repeat
    cl11960
    Location:310383
    Ig; Immunoglobulin domain
    cl15307
    Location:249281
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    35936374..35946624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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