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ZBED2 zinc finger BED-type containing 2 [ Homo sapiens (human) ]

Gene ID: 79413, updated on 9-Jun-2025
Official Symbol
ZBED2provided by HGNC
Official Full Name
zinc finger BED-type containing 2provided by HGNC
Primary source
HGNC:HGNC:20710
See related
Ensembl:ENSG00000177494 MIM:615246; AllianceGenome:HGNC:20710
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of keratinocyte differentiation. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Biased expression in thyroid (RPKM 46.0), lung (RPKM 7.6) and 2 other tissues See more
Orthologs
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Location:
3q13.13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (111592900..111595346, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (114313709..114316155, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (111311747..111314193, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374039 Neighboring gene ATPase H+ transporting V0 subunit c pseudogene 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:111227353-111228552 Neighboring gene CD96 molecule Neighboring gene NECTIN2 pseudogene 1 Neighboring gene MPRA-validated peak4766 silencer Neighboring gene MPRA-validated peak4767 silencer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:111328685-111329884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:111335350-111335850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:111335851-111336351 Neighboring gene NT5C3A pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20225 Neighboring gene PLCXD2 antisense RNA 1 Neighboring gene phosphatidylinositol specific phospholipase C X domain containing 2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description
Preferred Names
zinc finger BED domain-containing protein 2
Names
zinc finger, BED domain containing 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024508.5NP_078784.2  zinc finger BED domain-containing protein 2

    See identical proteins and their annotated locations for NP_078784.2

    Status: VALIDATED

    Source sequence(s)
    AC055748, BC071956, CV575511
    Consensus CDS
    CCDS2960.2
    UniProtKB/Swiss-Prot
    D3DN62, Q9BTP6
    Related
    ENSP00000321370.4, ENST00000317012.5
    Conserved Domains (1) summary
    smart00614
    Location:56109
    ZnF_BED; BED zinc finger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    111592900..111595346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    114313709..114316155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)