ptena phosphatase and tensin homolog A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptenaprovided by ZNC
Official Full Name: phosphatase and tensin homolog Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3776
See related: Ensembl:ENSDARG00000071018 AllianceGenome:ZFIN:ZDB-GENE-030131-3776
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:73086; wu:fc52g04
Summary: Enables lipid phosphatase activity. Acts upstream of or within several processes, including hepatocyte proliferation; lifelong otolith mineralization; and phosphatidylinositol dephosphorylation. Predicted to be located in several cellular components, including PML body; dendritic spine; and postsynaptic density. Predicted to be active in several cellular components, including cytosol; nucleus; and plasma membrane. Is expressed in several structures, including nervous system; oocyte; otic vesicle; presumptive neural retina; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 17

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	17	NC_133192.1 (24991233..25019503, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (23650569..23674522, complement)

Chromosome 17 - NC_133192.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the role of Pten during zebrafish embryonic development
Title: Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development.
Vegfaa has a crucial role in angiogenesis and vegfaa expression was upregulated in embryos lacking functional Pten.
Title: Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish.
ptena(+/-)ptenb(-/-) fish develop tumors at a relatively high incidence (10.2%) and most tumors developed close to the eye (26/30). The tumor masses were associated with the retrobulbar vascular network and diagnosed as hemangiosarcomas.
Title: Haploinsufficiency of the genes encoding the tumor suppressor Pten predisposes zebrafish to hemangiosarcoma.
Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia.
Title: Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia.
Overexpression of Ptena alters phospho-Akt levels and impairs cell movements associated with gastrulation.
Title: Altering PI3K-Akt signalling in zebrafish embryos affects PTEN phosphorylation and gastrulation.
Whereas Ptena and Ptenb have redundant functions in embryonic development, they apparently do not have completely overlapping functions later in life.
Title: Zebrafish pten genes have overlapping and non-redundant functions in tumorigenesis and embryonic development.
ptena and ptenb encode functional enzymes and each plays a distinct role during zebrafish embryogenesis.
Title: Ptena and ptenb genes play distinct roles in zebrafish embryogenesis.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables lipid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell motility	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hepatocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lifelong otolith mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myeloid cell activation involved in immune response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myeloid cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell communication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular component organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of developmental process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of multicellular organismal process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylinositol dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylinositol dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macromolecule metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of biological quality	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: phosphatase and tensin homolog A

Names: phosphatase and tensin-like protein A

NP_957002.2

EC 3.1.3.67

XP_009291324.1

EC 3.1.3.67

XP_073783664.1

EC 3.1.3.67

XP_073783665.1

EC 3.1.3.67

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200708.2 → NP_957002.2 phosphatase and tensin homolog A

Status: PROVISIONAL

Source sequence(s)

BC059457

UniProtKB/TrEMBL

A0A8M1PHN1, Q6PC66

Related

ENSDARP00000157011.1, ENSDART00000182952.1

Conserved Domains (2) summary

smart00404
Location:94 → 185

PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif

pfam10409
Location:190 → 400

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

NC_133192.1 Reference GRCz12tu Primary Assembly

Range

24991233..25019503 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009293049.5 → XP_009291324.1 phosphatase and tensin homolog A isoform X1

See identical proteins and their annotated locations for XP_009291324.1

UniProtKB/TrEMBL

A0A8M3AIZ0, Q6PC66, Q6TGR7

Related

ENSDARP00000109367.2

Conserved Domains (2) summary

smart00404
Location:94 → 185

PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif

pfam10409
Location:190 → 377

PTEN_C2; C2 domain of PTEN tumour-suppressor protein
XM_073927564.1 → XP_073783665.1 phosphatase and tensin homolog A isoform X3

UniProtKB/TrEMBL

Q6PC66
XM_073927563.1 → XP_073783664.1 phosphatase and tensin homolog A isoform X2

UniProtKB/TrEMBL

Q6PC66