il2rb interleukin 2 receptor, beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: il2rbprovided by ZNC
Official Full Name: interleukin 2 receptor, betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080108-2
See related: Ensembl:ENSDARG00000075720 AllianceGenome:ZFIN:ZDB-GENE-080108-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: il-2rb
Summary: Predicted to enable cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and immunoglobulin mediated immune response. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in head kidney. Human ortholog(s) of this gene implicated in asthma; immunodeficiency 63; myasthenia gravis; and visceral leishmaniasis. Orthologous to human IL2RB (interleukin 2 receptor subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	3	NC_133178.1 (23935322..23951607)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (25191452..25211422)

Chromosome 3 - NC_133178.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-2 receptor subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.