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BCL2L14 BCL2 like 14 [ Homo sapiens (human) ]

Gene ID: 79370, updated on 15-Jun-2019

Summary

Official Symbol
BCL2L14provided by HGNC
Official Full Name
BCL2 like 14provided by HGNC
Primary source
HGNC:HGNC:16657
See related
Ensembl:ENSG00000121380 MIM:606126
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCLG
Summary
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]
Expression
Biased expression in testis (RPKM 9.1), duodenum (RPKM 7.7) and 10 other tissues See more
Orthologs

Genomic context

See BCL2L14 in Genome Data Viewer
Location:
12p13.2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (12049844..12099695)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (12223873..12252629)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1252 Neighboring gene ETS variant 6 Neighboring gene microRNA 1244-4 Neighboring gene prothymosin alpha pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
intracellular organelle IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
apoptosis facilitator Bcl-2-like protein 14
Names
BCL2-like 14 (apoptosis facilitator)
apoptosis regulator BCL-G
bcl2-L-14
testicular tissue protein Li 26

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029375.1 RefSeqGene

    Range
    5001..33752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001370268.1NP_001357197.1  apoptosis facilitator Bcl-2-like protein 14 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC007537
  2. NM_001370269.1NP_001357198.1  apoptosis facilitator Bcl-2-like protein 14 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC007537
  3. NM_030766.1NP_110393.1  apoptosis facilitator Bcl-2-like protein 14 isoform 2

    See identical proteins and their annotated locations for NP_110393.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is also known as BCL-G short form. It contains an extra segment within the coding region, which results in a frameshift, when compared to variant 1. This variant encodes an isoform (2) that contains a shorter and distinct C terminus, as compared to isoform 1.
    Source sequence(s)
    AF281255
    Consensus CDS
    CCDS8646.1
    UniProtKB/Swiss-Prot
    Q9BZR8
    UniProtKB/TrEMBL
    A0A140VJF2
    Related
    ENSP00000266434.4, ENST00000266434.8
  4. NM_138722.1NP_620048.1  apoptosis facilitator Bcl-2-like protein 14 isoform 1

    See identical proteins and their annotated locations for NP_620048.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is also known as BCL-G long form. It encodes the longest isoform (1).
    Source sequence(s)
    AF281254
    Consensus CDS
    CCDS8645.1
    UniProtKB/Swiss-Prot
    Q9BZR8
    UniProtKB/TrEMBL
    A0A024RAR1
    Related
    ENSP00000379653.1, ENST00000396367.5
    Conserved Domains (1) summary
    cl02575
    Location:185319
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
  5. NM_138723.2NP_620049.1  apoptosis facilitator Bcl-2-like protein 14 isoform 1

    See identical proteins and their annotated locations for NP_620049.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a distinct 5' UTR region, and encodes the identical isoform (1), when compared to variant 1.
    Source sequence(s)
    AC007537, BC025778
    Consensus CDS
    CCDS8645.1
    UniProtKB/Swiss-Prot
    Q9BZR8
    UniProtKB/TrEMBL
    A0A024RAR1
    Related
    ENSP00000309132.4, ENST00000308721.9
    Conserved Domains (1) summary
    cl02575
    Location:185319
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    12049849..12099695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449186.1XP_024304954.1  apoptosis facilitator Bcl-2-like protein 14 isoform X2

  2. XM_024449185.1XP_024304953.1  apoptosis facilitator Bcl-2-like protein 14 isoform X1

    Conserved Domains (1) summary
    cl02575
    Location:188322
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
  3. XM_024449188.1XP_024304956.1  apoptosis facilitator Bcl-2-like protein 14 isoform X3

  4. XM_006719151.3XP_006719214.1  apoptosis facilitator Bcl-2-like protein 14 isoform X2

    See identical proteins and their annotated locations for XP_006719214.1

    UniProtKB/Swiss-Prot
    Q9BZR8
    UniProtKB/TrEMBL
    A0A024RAR1
    Conserved Domains (1) summary
    cl02575
    Location:185319
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
  5. XM_024449187.1XP_024304955.1  apoptosis facilitator Bcl-2-like protein 14 isoform X2

  6. XM_011520848.1XP_011519150.1  apoptosis facilitator Bcl-2-like protein 14 isoform X2

    See identical proteins and their annotated locations for XP_011519150.1

    UniProtKB/Swiss-Prot
    Q9BZR8
    UniProtKB/TrEMBL
    A0A024RAR1
    Conserved Domains (1) summary
    cl02575
    Location:185319
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
  7. XM_011520849.1XP_011519151.1  apoptosis facilitator Bcl-2-like protein 14 isoform X2

    See identical proteins and their annotated locations for XP_011519151.1

    UniProtKB/Swiss-Prot
    Q9BZR8
    UniProtKB/TrEMBL
    A0A024RAR1
    Conserved Domains (1) summary
    cl02575
    Location:185319
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_011332696.1 Reference GRCh38.p13 PATCHES

    Range
    18859..68693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138724.1: Suppressed sequence

    Description
    NM_138724.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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