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FCRL2 Fc receptor like 2 [ Homo sapiens (human) ]

Gene ID: 79368, updated on 16-Oct-2021

Summary

Official Symbol
FCRL2provided by HGNC
Official Full Name
Fc receptor like 2provided by HGNC
Primary source
HGNC:HGNC:14875
See related
Ensembl:ENSG00000132704 MIM:606509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCRH2; IFGP4; IRTA4; SPAP1; CD307b; SPAP1A; SPAP1B; SPAP1C
Summary
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Apr 2009]
Expression
Biased expression in lymph node (RPKM 14.2), spleen (RPKM 13.1) and 7 other tissues See more
Orthologs
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Genomic context

See FCRL2 in Genome Data Viewer
Location:
1q23.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (157745733..157777472, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157715523..157746922, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SON pseudogene 1 Neighboring gene voltage dependent anion channel 1 pseudogene 9 Neighboring gene Fc receptor like 1 Neighboring gene CD5 molecule like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell signaling NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Fc receptor-like protein 2
Names
IFGP family protein 4
SH2 domain containing phosphatase anchor protein 1
fc receptor homolog 2
immune receptor translocation-associated protein 4
immunoglobulin receptor translocation-associated protein 4
immunoglobulin superfamily Fc receptor, gp42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159488.2NP_001152960.1  Fc receptor-like protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001152960.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three alternate exons in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF459633, AK301113, AK303549
    UniProtKB/Swiss-Prot
    Q96LA5
    UniProtKB/TrEMBL
    B4DVJ9, B4E0W2
    Conserved Domains (3) summary
    smart00410
    Location:216288
    IG_like; Immunoglobulin like
    pfam13895
    Location:23102
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:108181
    Ig_3; Immunoglobulin domain
  2. NM_030764.4NP_110391.2  Fc receptor-like protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_110391.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF459633, AK303549, AY358130
    Consensus CDS
    CCDS1168.1
    UniProtKB/Swiss-Prot
    Q96LA5
    UniProtKB/TrEMBL
    B4E0W2
    Related
    ENSP00000355157.3, ENST00000361516.8
    Conserved Domains (3) summary
    smart00410
    Location:216288
    IG_like; Immunoglobulin like
    pfam13895
    Location:23102
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:108181
    Ig_3; Immunoglobulin domain

RNA

  1. NR_125358.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks four alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the reading frame found in variant 1.
    Source sequence(s)
    AF459633, BC069185
    Related
    ENST00000368181.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    157745733..157777472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002318.1XP_016857807.1  Fc receptor-like protein 2 isoform X6

    Conserved Domains (2) summary
    smart00409
    Location:216288
    IG; Immunoglobulin
    cl11960
    Location:120180
    Ig; Immunoglobulin domain
  2. XM_017002317.1XP_016857806.1  Fc receptor-like protein 2 isoform X5

  3. XM_011509976.2XP_011508278.1  Fc receptor-like protein 2 isoform X4

    Conserved Domains (3) summary
    smart00410
    Location:216288
    IG_like; Immunoglobulin like
    pfam13895
    Location:23102
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:108181
    Ig_3; Immunoglobulin domain
  4. XM_017002319.1XP_016857808.1  Fc receptor-like protein 2 isoform X7

  5. XM_017002316.1XP_016857805.1  Fc receptor-like protein 2 isoform X1

  6. XM_011509975.3XP_011508277.1  Fc receptor-like protein 2 isoform X3

    Conserved Domains (3) summary
    smart00410
    Location:216288
    IG_like; Immunoglobulin like
    pfam13895
    Location:23102
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:108181
    Ig_3; Immunoglobulin domain
  7. XM_011509974.3XP_011508276.1  Fc receptor-like protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011508276.1

    Conserved Domains (3) summary
    smart00410
    Location:216288
    IG_like; Immunoglobulin like
    pfam13895
    Location:23102
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:108181
    Ig_3; Immunoglobulin domain
  8. XM_006711535.3XP_006711598.1  Fc receptor-like protein 2 isoform X8

    Conserved Domains (3) summary
    smart00410
    Location:216288
    IG_like; Immunoglobulin like
    pfam13895
    Location:23102
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:108181
    Ig_3; Immunoglobulin domain

RNA

  1. XR_001737404.1 RNA Sequence

  2. XR_001737403.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138738.3: Suppressed sequence

    Description
    NM_138738.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  2. NM_138739.1: Suppressed sequence

    Description
    NM_138739.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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