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HMGN5 high mobility group nucleosome binding domain 5 [ Homo sapiens (human) ]

Gene ID: 79366, updated on 21-Dec-2019

Summary

Official Symbol
HMGN5provided by HGNC
Official Full Name
high mobility group nucleosome binding domain 5provided by HGNC
Primary source
HGNC:HGNC:8013
See related
Ensembl:ENSG00000198157 MIM:300385
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSBP1; NBP-45
Summary
This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009]
Expression
Broad expression in testis (RPKM 20.5), adrenal (RPKM 4.3) and 20 other tissues See more
Orthologs

Genomic context

See HMGN5 in Genome Data Viewer
Location:
Xq21.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (81113699..81201913, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (80369200..80457441, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 995, pseudogene Neighboring gene voltage dependent anion channel 1 pseudogene 1 Neighboring gene SH3 domain binding glutamate rich protein like Neighboring gene uncharacterized LOC105373284 Neighboring gene solute carrier family 9 member A2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
chromatin binding NAS
Non-traceable Author Statement
more info
PubMed 
nucleosomal DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
chromatin IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
high mobility group nucleosome-binding domain-containing protein 5
Names
nucleosomal binding protein 1
nucleosome-binding protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013234.1 RefSeqGene

    Range
    5030..93244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030763.3NP_110390.1  high mobility group nucleosome-binding domain-containing protein 5

    See identical proteins and their annotated locations for NP_110390.1

    Status: REVIEWED

    Source sequence(s)
    AF250329, AK094058, AL391294, DA745749
    Consensus CDS
    CCDS14448.1
    UniProtKB/Swiss-Prot
    P82970
    Related
    ENSP00000350848.2, ENST00000358130.7
    Conserved Domains (2) summary
    pfam01101
    Location:193
    HMG14_17; HMG14 and HMG17
    cl27511
    Location:61281
    Na_Ca_ex; Sodium/calcium exchanger protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    81113699..81201913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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