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OR5H2 olfactory receptor family 5 subfamily H member 2 [ Homo sapiens (human) ]

Gene ID: 79310, updated on 26-Oct-2022

Summary

Official Symbol
OR5H2provided by HGNC
Official Full Name
olfactory receptor family 5 subfamily H member 2provided by HGNC
Primary source
HGNC:HGNC:14752
See related
Ensembl:ENSG00000197938 AllianceGenome:HGNC:14752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR3-10
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR5H2 in Genome Data Viewer
Location:
3q11.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (98282505..98284070)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (100986200..100987765)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (98001349..98002914)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily H member 7 pseudogene Neighboring gene uncharacterized LOC105373999 Neighboring gene olfactory receptor family 5 subfamily H member 6 Neighboring gene olfactory receptor family 5 subfamily H member 8 (gene/pseudogene) Neighboring gene olfactory receptor family 5 subfamily K member 4

Genomic regions, transcripts, and products

Phenotypes

EBI GWAS Catalog

Description
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.
EBI GWAS Catalog

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
olfactory receptor 5H2
Names
olfactory receptor OR3-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005482.2NP_001005482.2  olfactory receptor 5H2

    Status: VALIDATED

    Source sequence(s)
    AC117473
    Consensus CDS
    CCDS33801.2
    Related
    ENSP00000347418.3, ENST00000355273.3
    Conserved Domains (1) summary
    cd15409
    Location:25303
    7tmA_OR5H-like; olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    98282505..98284070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    100986200..100987765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)