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OR52E1 olfactory receptor family 52 subfamily E member 1 (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 79296, updated on 22-Sep-2022

Summary

Official Symbol
OR52E1provided by HGNC
Official Full Name
olfactory receptor family 52 subfamily E member 1 (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:14766
See related
Ensembl:ENSG00000273085 AllianceGenome:HGNC:14766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR52E1P
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]
Annotation information
Annotation category: suggests misassembly
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Orthologs
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Genomic context

See OR52E1 in Genome Data Viewer
Location:
11p15.4
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (5069572..5070497)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (5126471..5127397)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5090802..5091727)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily J member 3 Neighboring gene olfactory receptor family 52 subfamily E member 2 Neighboring gene olfactory receptor family 52 subfamily S member 1 pseudogene Neighboring gene olfactory receptor family 52 subfamily E member 3 pseudogene

Genomic regions, transcripts, and products

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
olfactory receptor 52E1
Names
olfactory receptor, family 52, subfamily E, member 1 pseudogene
seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348221.2NP_001335150.1  olfactory receptor 52E1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the functional allele encoding the full-length protein.
    Source sequence(s)
    AB065801, AC113331
    UniProtKB/Swiss-Prot
    Q8NGJ3
    Conserved Domains (1) summary
    cd15952
    Location:24297
    7tmA_OR52E-like; olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_145505.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, noncoding) represents the reference genome allele, which does not encode a full-length protein and is predicted to be non-functional.
    Source sequence(s)
    AC113331
    Related
    ENST00000445557.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    5069572..5070497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791794.1 Reference GRCh38.p14 PATCHES

    Range
    65892..66818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    5126471..5127397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_003197.3: Suppressed sequence

    Description
    NG_003197.3: This RefSeq was removed because it is now thought that this gene does encode a protein.