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parlb presenilin associated, rhomboid-like b [ Danio rerio (zebrafish) ]

Gene ID: 792889, updated on 15-Jul-2026
Official Symbol
parlbprovided by ZNC
Official Full Name
presenilin associated, rhomboid-like bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110804-1
See related
Ensembl:ENSDARG00000020891 AllianceGenome:ZFIN:ZDB-GENE-110804-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
parl; parla
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in signal peptide processing. Predicted to be located in membrane. Is expressed in brain; heart; liver; and muscle. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Orthologous to human PARL (presenilin associated rhomboid like). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See parlb in Genome Data Viewer
Location:
chromosome: 15
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 15 NC_133190.1 (48360982..48377364)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 15 NC_007126.7 (45543313..45560633)

Chromosome 15 - NC_133190.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 12b Neighboring gene uncharacterized LOC141377933 Neighboring gene un-named sa32065 Neighboring gene claudin 15-like b Neighboring gene ATG16 autophagy related 16-like 1 (S. cerevisiae) Neighboring gene small Cajal body-specific RNA 6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Zebrafish Parla- and Parlb-deficiency affects dopaminergic neuron patterning and embryonic survival. Noble S, et al. J Neurochem, 2012 Jul. PMID 22506991
  2. Loss of parla Function Results in Inactivity, Olfactory Impairment, and Dopamine Neuron Loss in Zebrafish. Merhi R, et al. Biomedicines, 2021 Feb 18. PMID 33670667, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
presenilin-associated rhomboid-like protein, mitochondrial
Names
presenilin associated rhomboid like
presenilins-associated rhomboid-like protein, mitochondrial

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133190.1 Reference GRCz12tu Primary Assembly

    Range
    48360982..48377364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073924115.1 → XP_073780216.1  presenilin-associated rhomboid-like protein, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0AC58HE40

  2. XM_073924116.1 → XP_073780217.1  presenilin-associated rhomboid-like protein, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0AC58HE03

RNA

  1. XR_012391116.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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