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DCAF10 DDB1 and CUL4 associated factor 10 [ Homo sapiens (human) ]

Gene ID: 79269, updated on 23-Nov-2021

Summary

Official Symbol
DCAF10provided by HGNC
Official Full Name
DDB1 and CUL4 associated factor 10provided by HGNC
Primary source
HGNC:HGNC:23686
See related
Ensembl:ENSG00000122741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WDR32
Expression
Ubiquitous expression in testis (RPKM 8.3), thyroid (RPKM 6.2) and 25 other tissues See more
Orthologs
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Genomic context

See DCAF10 in Genome Data Viewer
Location:
9p13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (37800554..37867664)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37800551..37867661)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 1 Neighboring gene RN7SK pseudogene 171 Neighboring gene tRNA methyltransferase 10B Neighboring gene uncharacterized LOC105376037 Neighboring gene exosome component 3 Neighboring gene mitochondrial ribosomal protein S10 pseudogene 5 Neighboring gene solute carrier family 25 member 51 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase pseudogene 1 Neighboring gene thioredoxin related transmembrane protein 2 pseudogene 1 Neighboring gene RNA, U7 small nuclear 124 pseudogene Neighboring gene SH2 domain containing adaptor protein B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23201, MGC10765, MGC131781

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DDB1- and CUL4-associated factor 10
Names
WD repeat domain 32
WD repeat-containing protein 32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286810.2NP_001273739.1  DDB1- and CUL4-associated factor 10 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK309712, AL138752, BC108686, CB045943
    Consensus CDS
    CCDS75835.1
    UniProtKB/Swiss-Prot
    Q5QP82
    UniProtKB/TrEMBL
    A0A0A0MQT4
    Related
    ENSP00000242323.8, ENST00000242323.8
    Conserved Domains (2) summary
    sd00039
    Location:234
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:9146
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_024345.5NP_077321.3  DDB1- and CUL4-associated factor 10 isoform a

    See identical proteins and their annotated locations for NP_077321.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL138752, BC108686, CB045943, HY015327
    Consensus CDS
    CCDS6613.2
    UniProtKB/Swiss-Prot
    Q5QP82
    Related
    ENSP00000366953.3, ENST00000377724.8
    Conserved Domains (4) summary
    smart00320
    Location:517555
    WD40; WD40 repeats
    COG2319
    Location:171334
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:172207
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:164319
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    37800554..37867664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251577.4XP_005251634.1  DDB1- and CUL4-associated factor 10 isoform X1

    UniProtKB/Swiss-Prot
    Q5QP82
    Conserved Domains (3) summary
    COG2319
    Location:169518
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:172207
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:169519
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_017015128.1XP_016870617.1  DDB1- and CUL4-associated factor 10 isoform X3

  3. XM_005251578.4XP_005251635.1  DDB1- and CUL4-associated factor 10 isoform X2

    Conserved Domains (3) summary
    smart00320
    Location:451489
    WD40; WD40 repeats
    COG2319
    Location:169489
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:164223
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_017015129.1XP_016870618.1  DDB1- and CUL4-associated factor 10 isoform X4

    Conserved Domains (1) summary
    smart00320
    Location:216254
    WD40; WD40 repeats

RNA

  1. XR_002956808.1 RNA Sequence

  2. XR_929331.2 RNA Sequence

  3. XR_002956809.1 RNA Sequence

  4. XR_002956810.1 RNA Sequence

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